摘要
目的探讨血管紧张素转移酶基因(ACE)插入(I)或缺失(D)多态性与神经胶质瘤的相关性。方法采用聚合酶链(PCR)反应方法检测152例神经胶质瘤患者和199例健康对照组ACE I/D多态性。结果与缺失纯合型(DD)基因型相比,杂合子ID基因型显著增加了神经胶质瘤的发病风险(P=0.038);根据性别和病理分级进行亚组分析,未发现ACE I/D多态性在性别和不同病理分级中存在明显差异(P>0.05)。结论 ACE I/D多态性与神经胶质瘤的发病具有相关性。
Objective To investigate the association between angiotensin I-converting enzyme (AC) Einsertion (I) and deletion (D) polymorphism and risk of glioma. Methods The ACE I/D polymorphism was genotyped in 152 patients with glioma and 199 healthy controls using polymerase chain reaction (PCR) strategy. Results The ID genotype was associated with an increased risk of glioma compared with deletion and deletion (DD) genotype (P=0.038). When stratified according to sex and clinical stages, no significant association between the ACE I/D polymorphism and sex and maliganey was observed. Condusion ACE I/D polymorphism may be a risk factor for the development of glioma.
出处
《中华神经外科疾病研究杂志》
CAS
2013年第2期106-108,共3页
Chinese Journal of Neurosurgical Disease Research