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mTOR信号通路与胃癌复发转移关系的研究进展 被引量：3

Relations of mTOR signal pathway with recurrence and metastasis of gastric cancer: recent progress
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摘要 mTOR及其信号通路在胃癌的复发和转移过程中起重要作用,以mTOR为靶点的靶向药物联合化疗药物对于克服胃癌复发及转移治疗胃癌具有广阔的临床应用前景。笔者就国内、外近年来有关mTOR信号通路在胃癌复发转移中作用机制的研究进展作一综述。 mTOR and its signal pathway components are closely related to recurrence and metastasis of gastric cancer, so the targeted drugs against mTOR combined with chemotherapy agents show great application potentials for avoiding the recurrence and metastasis of gastric cancer. In this paper, the authors present the recent progress in the mechanisms underlying mTOR signaling pathway-mediated recurrence and metastasis of gastric cancer.
作者 朱优龙 姜波健 俞继卫
机构地区 上海交通大学医学院附属第三人民医院普外一科
出处 《中国普通外科杂志》 CAS CSCD 北大核心 2013年第4期489-493,共5页 China Journal of General Surgery
基金 国家自然科学基金资助项目(81101850) 上海市教委基金资助项目(12YZ047)
关键词 胃肿瘤 MTOR 肿瘤复发 肿瘤转移 综述文献 Stomach Neoplasms mTOR Neoplasm Recurrence Neoplasm Metastasis Review
分类号 R735.2 [医药卫生—肿瘤]
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参考文献40

  • 1Sarbassov DD, Guertin DA, Ali SM, et al. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex[J]. Science, 2005, 307(5712): 1098-1101.
  • 2Gibbons JJ, Abraham RT, Yu K. Mammalian target of rapamycin: discovery of rapamycin reveals a signaling pathway important for normal and cancer cell growth[J]. Semin Oncol, 2009, 36(Suppl 3):S3-S17.
  • 3Dworakowska D, Wlodek E, Leontiou CA, et al. Activation of RAF/ MEK/ERK and PI3K/AKT/mTOR pathways in pituitary adenomas and their effects on downstream effectors[J]. Endocr Relat Cancer, 2009, 16(4):1329-1338.
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  • 9Cappetta A, Lonardi S, Pastorelli D, et al. Advanced gastric cancer (GC) and cancer of the gastro-oesophageal junction (GEJ): focus on targeted therapies[J]. Crit Rev Oncol Hematol, 2012, 81(1):38-48.
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中国普通外科杂志
2013年 第4期

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