获得性免疫缺陷综合征继发弓形体脑病的MRI特征

MRI characteristics of toxoplasmic encephalitis secondary to AIDS

目的探讨获得性免疫缺陷综合征(AIDS)合并弓形体脑病的特征性MRI改变。方法回顾性分析临床资料完整的15例AIDS合并弓形体脑病的MRI改变。结果 14例脑内病灶多发,1例单发;T1WI病变呈中等偏低的斑片状、团块状信号,边缘可见高信号环,T2WI多表现为高信号,边缘可见低信号环,周围水肿效应明显;增强后呈结节状、环状、半环状、连环状强化。经抗弓形体药物治疗后,临床症状均有好转,复查MR显示病灶缩小。结论 AIDS合并弓形体脑病具有一定特征性MRI改变;MRI对诊断本病具有重要价值。

Objective To explore MRI characteristics of acquired immune deficiency syndrome （AIDS） complicated with toxoplasmic encephalitis （TE）. Methods The clinical and imaging data of 15 AIDS patients complicated with TE were ret- rospectively analyzed. Results Multiple lesions appeared in 14 patients, while isolated lesion was found in 1 patient. The lesions displayed as lower-middle intensity signal on T1WI with hyperintensity rims, and higher signal mostly on T2WI with lower intensity rim around them. There was marked peripheral edema effect outside the lesions. All lesions showed rim or multi-rim or hal＆rim enhancement in MRI. The treatment of anti-toxoplasma had effect for all patients. Conclusion AIDS complicated with TE has certain imaging characteristics. MRI owns an important value in the diagnosis.