摘要
介绍了假单孢菌外毒素 A的理化性质 ,分子结构与功能的关系以及假单孢菌外毒素 A的应用前景。
出处
《生物学通报》
北大核心
2000年第9期10-13,共4页
Bulletin of Biology
参考文献5
-
1Gray, G. L. Snith, D. H, , Baldridse, J. S ., Harkins, R.N. ,Vasil ,M. L. , et al. Cloning,nucleotide sequence,and expression in Escherichia coli of the exotoxin A structural gene of Pseudomonas aeruginosa, proc. Natl. Acad.Sci USA 1984,81:2645-49.
-
2Seetharam,S.et al. ,Increased cytotoxic activity of Pseudomonas exotoxin and two chimeric toxins ending in KDEL, J. Biol. Chem. ,1990,226:17376-17381.
-
3Kreitman R J, Pastan I., Importance of the glutamate residue of KDEL in increasing the cytotoxicity of Pseudomonas exotoxin derivatives and for increased binding to the KDEL receptor ,Biochem. J. , 1995,307:29-37.
-
4Puri,RK et al, ,Preeilncal developmeat of a reeombinant toxin containing circularly permuted interleukin 4 and truncated Pseudomonasexotoxin .for therapy of malignant astrocytoma, Cancer Res. , 1996, 56: 5631-5637.
-
5Pai,LH et al. ,Treatment of advaaced solid tumor with immunotoxin LMB-1, an antibldy linked to Pseudomonasexotoxin,Nat. Med. 1996,2:350-353 .
同被引文献15
-
1李树民,李咏梅,冯书章,郭学军,孙洋,朱平.EGF-PE35KDEL嵌合毒素对Hela细胞的毒性作用[J].中国肿瘤生物治疗杂志,2005,12(2):120-123. 被引量:1
-
2祁志荣,李虹.PE类重组免疫毒素的研究进展[J].微生物学免疫学进展,2006,34(1):50-53. 被引量:7
-
3AQEILAN R, KEDAR R, BEN-YEHUDAH A , et al. Mechanism of action of interleukin-2 ( IL-2)-Bax, an apoptosis-inducing chimaeric protein targeted against cells expressing the IL-2 receptor[ J]. Biochem J, 2003, 370 (Pt 1 ) : 129 -140.
-
4YATES S P, MERRILL A R. A catalytic loop within Pseudomonas aeruginosa exotoxin A modulates its transferase activity[ J]. JBiol Chem, 2001, 276(37) : 35 029 -35 036.
-
5ARMSTRONG S , YATES S P, MERRILL A R. Insight into the catalytic mechanism of pseudomonas aeruginosa exotoxin A [ J ]. Biochem, 2002, 277(48) : 46 669 -46 675.
-
6PATI D, HABIBI H R. Inhibition of human hepatocarcinoma cell pro-liferation by mammalian and fish gonadotrop in-releasing hormones[J]. Endocrinology, 1995, 136( 1 ) : 75 - 84.
-
7TAUPIAC M P, BEBIEN M, ALAMI M, et al. A deletion within the translocation domain of Pseudomonas exotoxin A enhances translocation efficiency and cytotoxicity concomitantly[ J]. Mol Microbiol, 1999, 31 (5) : 1385 -93.
-
8PASTAN I H, FITZGERALD D J. Recombinant pseudomonas exotoxin with increased activity: US, 5602095 [ P ]. 1997 -02 -11.
-
9BORNHORST J A, FALKE J J. Purification of proteins using polyhistidine affinity tags [ J ]. Methods Enzymol, 2000,326 : 245 - 254.
-
10CROWE J, MASONE B S, Ribbe J. One-step purification of recombinant proteins with the 6xHis tag and Ni-NTA resin[ J]. Mol Biotechnol, 1995,4 ( 3 ) :247 - 258.
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