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不同程度阿尔茨海默病患者血清BDNF水平变化 被引量：3

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摘要 阿尔茨海默病（AD）是一种以进行性认知障碍和记忆能力损害为主的中枢神经系统退行性疾病。其病理特征包括血管和细胞外的β-淀粉样沉积（淀粉斑）、
作者 查显友 周燕 王莲娥 费玉娥
机构地区 嘉兴市康慈医院
出处 《浙江医学》 CAS 2013年第5期405-406,共2页 Zhejiang Medical Journal
关键词 阿尔茨海默病患者 水平变化 BDNF 中枢神经系统退行性疾病 淀粉样沉积 血清 记忆能力 认知障碍
分类号 R749.16 [医药卫生—神经病学与精神病学]
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参考文献7

  • 1解恒革.阿尔茨海默病的流行病学[J].中国全科医学,2001,4(12):933-934. 被引量：7
  • 2Peng S Y, Wuu J, Mufson E J, et al. Precursor form of brain-de- rived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer's disease[J]. J Neurochem, 2005, 93:1412.
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  • 5R ssler O G, Giehl K M, Thiel G. Neuroprotection of immortalized hippocampal neurones by brain-derived neurotrophic factor and Raf-1 protein kinase:role of extracellular sign al regulated protein kinase and phosphatidylinositol3-kinase[J]. Neurechem, 2004, 88(5): 1240-1252.
  • 6Baharia M, Renata B, Isabelle B, et al. Glial cell line-derived neurotrophic factor $ stimulated phosphatidylin0sitol 3 -kinase and Akt activities exert opposing effects on the ERK pathway[J]. Biological Chem, 2001,276(48):45307-45319.
  • 7Laske C, St ransky E, Leyhe T, et al. Stage-dependent BDNF serum concentrations in Alzheimer's disease[J]. J Neural Transm, 2006, 113(9):1217-1224.

共引文献6

同被引文献34

  • 1Adlard PA,Cummings BJ.Alzheimer's disease-a sum greater than its parts?[J].Neurobiol Aging,2004,25:725-733.
  • 2Diniz BS,Teixeira AL.Brain-derived neurotrophic factor and Alzheimer' s disease:physiopathology and beyond[J].Neuromol Med,2011,13:217-222.
  • 3Klein AB,Williamson R,Santini MA,et al.Blood BDNF concentrations reflect brain-tissue BDNF levels across species[J].Int J Neuropsychoph,2011,14 (3):347-353.
  • 4Poon WW,Blurton-Jones M,Tu CH,et al.Beta-amyloid impairs axonal BDNF retrograde trafficking[J].Neurobiol Aging,2011,32(5):821-833.
  • 5Chen TJ,Wang DC,Chen SS.Amyloid-beta interrupts the PI3 K-Akt-mTOR signaling pathway that could be involved in brain-derived neurotrophic factor-induced Arc expression in rat cortical neurons[J].J Neurosci Res,2009,87:2297-2307.
  • 6Nagahara AH,Merrill DA,Coppola G,et al.Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer' s disease[J].Nat Med,2009,15:331-337.
  • 7Yasutake C,Kuroda K,Yanagawa T,et al.Serum BDNF,TNF-a and IL-1βlevels in dementia patients,comparison between Alzheimer's disease and vascular dementia[J].Eur Arch Psy Clin N,2006,256:402-406.
  • 8Laske C,Stransky E,Leyhe T,et al.BDNF serum and CSF concentrations in Alzheimer's disease,normal pressure hydrocephalus and healthy controls[J].J Psychiatr Res,2007,41:387-394.
  • 9Forlenza OV,Diniz BS,Teixeira AL,et al.Effect of brainderived neurotrophic factor Val66Met polymorphism and serum levels on the progression of mild cognitive impairment[J].World J Biol Psychia,2010,11:774-780.
  • 10Lee JG,Shin BS,You YS,et al.Decreased serum brainderived neurotrophic factor levels in elderly Korean with dementia[J].Psychiat Invest,2009,6:299-305.

引证文献3

二级引证文献13

浙江医学
2013年 第5期

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