不同程度阿尔茨海默病患者血清BDNF水平变化
被引量:3
摘要
阿尔茨海默病(AD)是一种以进行性认知障碍和记忆能力损害为主的中枢神经系统退行性疾病。其病理特征包括血管和细胞外的β-淀粉样沉积(淀粉斑)、
出处
《浙江医学》
CAS
2013年第5期405-406,共2页
Zhejiang Medical Journal
参考文献7
-
1解恒革.阿尔茨海默病的流行病学[J].中国全科医学,2001,4(12):933-934. 被引量:7
-
2Peng S Y, Wuu J, Mufson E J, et al. Precursor form of brain-de- rived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer's disease[J]. J Neurochem, 2005, 93:1412.
-
3Karege F, Schwald M, Cisse M. Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets[J]. Neurosci Lett, 2002, 328(3):261-264.
-
4Szatmari E, Kalita K B, Kharebava G, et al. Role of kinase sup- pressor of Ras-1 in neuronal survival signaling by ext meellular signal-regulated kinase 1/2[J]. Neurosci, 2007, 27(42):11389- 11400.
-
5R ssler O G, Giehl K M, Thiel G. Neuroprotection of immortalized hippocampal neurones by brain-derived neurotrophic factor and Raf-1 protein kinase:role of extracellular sign al regulated protein kinase and phosphatidylinositol3-kinase[J]. Neurechem, 2004, 88(5): 1240-1252.
-
6Baharia M, Renata B, Isabelle B, et al. Glial cell line-derived neurotrophic factor $ stimulated phosphatidylin0sitol 3 -kinase and Akt activities exert opposing effects on the ERK pathway[J]. Biological Chem, 2001,276(48):45307-45319.
-
7Laske C, St ransky E, Leyhe T, et al. Stage-dependent BDNF serum concentrations in Alzheimer's disease[J]. J Neural Transm, 2006, 113(9):1217-1224.
共引文献6
-
1李福胜,王静,何明大.脑源性神经营养因子对阿尔茨海默病的作用[J].实用预防医学,2007,14(4):1320-1323. 被引量:5
-
2张敏.阿尔茨海默病与脑源性神经营养因子的关系[J].海南医学,2010,21(2):15-17. 被引量:4
-
3张敏.甲状腺激素与阿尔茨海默病的关系[J].中国老年学杂志,2010,30(6):750-751. 被引量:5
-
4刘静祎,王可,史瑞红,秦华平,高峰,王晔,赵欣,刘慧荣,张策.大鼠大脑皮质中Omi/HtrA2的年龄分布差异性及其可能的意义[J].中国现代医生,2010,48(21):9-13. 被引量:1
-
5刘宁,张俊龙,郭蕾.阿尔茨海默病流行病学现状[J].辽宁中医药大学学报,2011,13(1):35-36. 被引量:19
-
6王晶.我国阿尔茨海默病的流行现状及预防措施[J].亚太传统医药,2011,7(2):157-158. 被引量:35
同被引文献34
-
1Adlard PA,Cummings BJ.Alzheimer's disease-a sum greater than its parts?[J].Neurobiol Aging,2004,25:725-733.
-
2Diniz BS,Teixeira AL.Brain-derived neurotrophic factor and Alzheimer' s disease:physiopathology and beyond[J].Neuromol Med,2011,13:217-222.
-
3Klein AB,Williamson R,Santini MA,et al.Blood BDNF concentrations reflect brain-tissue BDNF levels across species[J].Int J Neuropsychoph,2011,14 (3):347-353.
-
4Poon WW,Blurton-Jones M,Tu CH,et al.Beta-amyloid impairs axonal BDNF retrograde trafficking[J].Neurobiol Aging,2011,32(5):821-833.
-
5Chen TJ,Wang DC,Chen SS.Amyloid-beta interrupts the PI3 K-Akt-mTOR signaling pathway that could be involved in brain-derived neurotrophic factor-induced Arc expression in rat cortical neurons[J].J Neurosci Res,2009,87:2297-2307.
-
6Nagahara AH,Merrill DA,Coppola G,et al.Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer' s disease[J].Nat Med,2009,15:331-337.
-
7Yasutake C,Kuroda K,Yanagawa T,et al.Serum BDNF,TNF-a and IL-1βlevels in dementia patients,comparison between Alzheimer's disease and vascular dementia[J].Eur Arch Psy Clin N,2006,256:402-406.
-
8Laske C,Stransky E,Leyhe T,et al.BDNF serum and CSF concentrations in Alzheimer's disease,normal pressure hydrocephalus and healthy controls[J].J Psychiatr Res,2007,41:387-394.
-
9Forlenza OV,Diniz BS,Teixeira AL,et al.Effect of brainderived neurotrophic factor Val66Met polymorphism and serum levels on the progression of mild cognitive impairment[J].World J Biol Psychia,2010,11:774-780.
-
10Lee JG,Shin BS,You YS,et al.Decreased serum brainderived neurotrophic factor levels in elderly Korean with dementia[J].Psychiat Invest,2009,6:299-305.
引证文献3
-
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-
2胡卫红,丁宇杰,陆光华,徐韩,李霞,肖世富.阿尔茨海默病患者血清脑源性神经营养因子水平研究[J].精神医学杂志,2014,27(6):424-426. 被引量:9
-
3李泽美,郭君萍,张小兰,钟爱芳,方侠辉,程灶火.外周血脑源性神经营养因子与阿尔茨海默病关联性的Meta分析[J].中华行为医学与脑科学杂志,2023,32(1):87-94. 被引量:2
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-
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-
2陈丽.脑源性神经营养因子联合用药缓解阿尔茨海默的临床分析[J].中外医学研究,2016,14(16):144-146.
-
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-
4吴桂梅.血液脑源性神经营养因子水平与阿尔茨海默病关系的Meta分析[J].社区医学杂志,2016,14(20):1-3. 被引量:3
-
5李春,安琳.阿尔茨海默病与治疗药物的研究进展[J].天津药学,2017,29(2):67-70. 被引量:3
-
6邓育,娄元菊,钟明洁,邓丽.美金刚联合抗抑郁药物治疗阿尔茨海默病伴焦虑抑郁激越症状的临床疗效[J].中国药物经济学,2018,13(8):48-51. 被引量:5
-
7操军,陈小容,况利,陈建梅,艾明,甘窈,王我,吕臻,何静澜.不同年龄段抑郁症患者血清脑源性神经营养因子水平研究[J].精神医学杂志,2020,33(1):7-10. 被引量:4
-
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-
9张金娜,颜蓉.外周血BDNF、miR-132及NfL对遗忘型轻度认知障碍患者向阿尔茨海默病转化的风险预测价值[J].现代实用医学,2023,35(8):1008-1011.
-
10曾丝丝,廖恒,赵学青.美金刚与多奈哌齐治疗阿尔茨海默病患者的临床疗效比较[J].当代医学,2023,29(14):60-64.
-
1王长福,肖阳,王秋红,武立华,匡海学.阿尔茨海默病与Aβ及其衍生物的关系研究进展[J].中国老年学杂志,2013,33(9):2208-2212. 被引量:2
-
2严斌,何月,周国庆.阿尔茨海默病的免疫治疗:现状及思考[J].实用医学杂志,2014,30(11):1842-1844. 被引量:4
-
3胡海涛,杨杰,钱亦华,张樟进,王唯析,胡晓丹.续断对Alzheimer病模型大鼠海马结构淀粉样沉积的影响[J].中国老年学杂志,1999,19(3):160-161. 被引量:20
-
4张志刚,马旭艳.铜锌等过渡金属离子与Aβ肽作用研究进展[J].山西大学学报(自然科学版),2007,30(1):83-87. 被引量:3
-
5蒋圣娟,孙振令,张红雨.阿尔茨海默氏症分子病理学及治疗方法的研究进展[J].山东理工大学学报(自然科学版),2003,17(1):94-99. 被引量:5
-
6邓少嫦,黄韧.硫酸乙酰肝素蛋白聚糖与阿尔茨海默病[J].中国神经精神疾病杂志,2006,32(1):91-92. 被引量:1
-
7冯改丰,胡海涛,靳辉,王唯析,钱亦华.融合蛋白CAC免疫对大鼠海马内注射β-淀粉样肽的作用[J].南方医科大学学报,2011,31(7):1236-1239. 被引量:1
-
8邵梅,陈生弟,刘振国.水溶性β-淀粉样蛋白25-35片段诱致大鼠嗜铬细胞瘤细胞凋亡[J].中国神经免疫学和神经病学杂志,2002,9(1):24-28. 被引量:8