血管内皮细胞的Cl^-通道──电特性和有关细胞功能

Chloride channels in vascular endothelial cells-electrophysiological characters and functions

内皮细胞在心血管系统具有重要功能，除通过分泌内皮舒张因子──一氧化氮（NO）及收缩性物质内皮素等控制血管平滑肌张力外，并能调节血管通透性。近年来发现内皮细胞上的C1-通道能调节细胞体积和细胞膜电位的稳定性。通过离子通道调控膜电位这一机理，能较好地理解血管内皮的功能，并可望由此开拓新型血管药物。本文综述了内皮细胞的C1-通道的电生理特性、类别，并探讨该通道调控细胞体积、NO的分泌及调控细胞膜电位的可能原理及方式。

Endothelial cells plny an active role in regulating vascular permeability aJnd contribute to the control of smooth muscle tone via secreting both endothelial-derived relaxing factor, nitric oxide,and constricting factor endothelin .Chloride channels in vaJscular endothelum appear to play a significant role including volume rcgulation and stabilization of membrane potential. The ion channels controlling the membrane potential are critical to the understanding of endothelial function. We summarized tI1e electrophysiological characters and classification of endothelial chloride channels, and explore the way in which the channels could control volume, secretion and membranepotential.