湖北地区伤寒沙门菌耐药性检测

SURVEILLANCE ON S.TYPHE RESISTANCE IN HUBEI

目的 报道 1999年湖北地区 15所医院分离的 80株伤寒沙门菌对 11种抗菌药物的耐药状况并与 1996年资料比较。方法 药敏试验采用纸片扩散法。用 WHONET- 4软件进行数据分析。结果 氨苄西林 (P<0 .0 5 )、哌拉西林 (P<0 .0 1)、头孢噻肟 (P<0 .0 1)敏感性下降具有统计学意义 ;临床常用于治疗伤寒的氨苄西林、氯霉素、环丙沙星对伤寒沙门菌仍保持高敏感性 ,分别为 89.5 %、96 % 95 .7%。结论 1999年伤寒沙门菌对临床常用抗菌药物敏感性均比

Objective To investigate in vitro antibacterial activity of 11 antibiotics against S.typhi iso lates from Hubei in 1999 and comparision with data in 1996.Method:The zone diameters of 80 isolates were determined by standard disc diffusion testing.Results The suscepotibility rate were decrcased obvious ly in Ampicillin( P <0.05),Piperacillin( P <0.01),Cefotaxime( P <0FF.01).However,S.typhi were also sus ceoptible to ampicillin、chloramphoid and ciprofloxicin, 89.5%、96% and 95.7%,spectively.Conclusions:The rates of susceptibility of all antimicrobial agents studied were lower in 1999 than in 1996.