蝎毒抗癫痫作用与微生态调节剂的关系

THE RELATIONSHIP BETWEEN ANTIEPILEPTIC EFFECT OF SCORPION VENOM AND MICROECOLOGICAL MODULAOR

:一次颈部皮下给予海人酸 (Kainic acid,KA ,10 m g/ kg)诱发 SD大鼠出现急性癫痫发作后 ,将实验组动物随机分为 3组 ,每天灌胃分别给予生理盐水、微生态调节剂 [活菌数 4× 10 9个 (0 .4ml)只 ]和蝎毒粗提液 (SV,10 0 mg/ kg)。 10天后再次给予同样剂量的 KA检测癫痫敏感性 ,行为结果经统计学处理后表明 ,两者均可明显抑制动物癫痫敏感性的形成。免疫组化结果表明 ,两者均可防止海马硬化的形成。

After the seizure induced by convulsive dose of kainic acid(KA,10mg/kg)in SD rats of experiment group, the ras were divided into three groups, which treaed with the saline、scorpion venom(SV)and microecological modulator. Seizure susecptibility was examined by administrating the same dose of KA. Behavior study showed that both the SV and microecological modulator could block seizure susceptibility. And immunohistochemistry results indicated both of them could prevent the formation of the hippocampal sclerosis. It suggested that the microecological modulator may be the important reason in antiepileptic effect of SV