深圳市福田区2009-2011年疑似预防接种异常反应监测分析

Analysis on monitoring of adverse events following immunization in Futian District,Shenzhen City during 2009 to 2011

目的了解深圳市福田区2009-2011年疑似预防接种异常反应(adverse events following immuniza-tion,AEFI)的发生及分布情况,为计划免疫相关政策的制定提供依据。方法采用描述性流行病学方法对2009-2011年AEFI的监测资料进行分析。结果全区2009-2011年共报告AEFI 666例,其中一般反应425例,发生率17.87/10万;异常反应155例,发生率6.52/10万。<1岁儿童306例,占45.95%。异常反应以过敏性皮疹为主(57.42%),一般反应以发热红肿硬结为主(96.00%)。7价肺炎疫苗AEFI发生率最高,其次是麻风二联疫苗和五联疫苗。结论深圳市福田区AEFI监测系统运行正常,疫苗的安全性较好;<1岁儿童为重点监测对象;7价肺炎疫苗、麻风二联疫苗和五联疫苗是重点监测的疫苗。

Objective To study the characteristics of adverse events following immunization in Futian District dur- ing 2009 to 2011, and provide basis for relevant planned immunization policies. Methods Descriptive epidemiological method was used to analyze the date collected through adverse events following immunization （ AEFI ） surveillance system from 2009 to 2011. Results A total of 666 eases were reported in the city from 2009 to 2011. The general response cases were 425 and the incidence rate was 17.87 per ten thousand, while the abnormal reaction cases were 155 and the incidence rate was 6. 52 per ten thousand. 306 patients were less than one year old and accounted for 45.95%. 57.42% of abnormal reaction cases were allergic rashes. 96.00% of general responses were fever, swelling and seleroma. The top three vac- cines leading to AEFI were 7-valent pneumovax, measles rubella combination vaccine and pentavaceine. Conclusions O- verall, the implementation of AEFI surveillance system was good and the safety of vaccines was satisfactory. The emphasis of AEFI monitoring was children less than one year old. 7-valent PCV, measles rubella combination vaccine and pentavae- cine were the key monitoring vaccines.