高频率心脏起搏器在犬持续性房颤模型的应用

Application of high-frequency pacemaker in a canine model of persistent atrial fibrillation

目的探讨应用高频率心脏起搏器建立持续性犬房颤模型的方法并验证此模型的有效性。方法 22只健康杂种犬分为A组(持续性房颤模型组,n=12)和B组(假手术组,n=10),通过电生理研究比较两组不应期变化、房颤可诱导性和持续时间。结果 A组犬左、右房面积显著增大,二尖瓣和三尖瓣瓣膜出现不同程度返流,测量的6个部位有效不应期均显著缩短(P<0.05)。与B组[(4.4%±8.4%),(1.5±3.4)s]相比,A组犬[(80.0%±17%),(26.0±5.9)min]房颤可诱导性与房颤最长持续时间均显著提高(P<0.05)。结论该方法建立的犬模型可以作为非器质性心脏病所致房颤研究的良好模型。

Objective To develop the model of persistent atrial fibrillation in canine with high-frequency pacemaker and to verify the efficiency of the model. Methods Twenty-two mongrel dogs were divided into two groups：twelve dogs （ Group A） were induced persistent atrial fibrillation and ten dogs （ Group B） were sham- operated. Two-dimensional echocardiography was performed in Group A to assess the effects of rapid atrial pacing on atrial size and valves. Electrophysiology test was performed to determine the effects of rapid atrial pacing on effective refractory period, atrial fibrillation inducibility and duration of atrial fibrillation of the two groups. Results After eight-week rapid pacing, marked biatrial enlargement was documented and valve regurgitation in different extent were inspected in Group A. Effective refractory period in the six regions decreased significantly in Group A（ P 〈 0.05 ）. Compared with Group B [ （4.4% ± 8.4% ） , （ 1.5 ±3.4） s] , atrial fibrillation inducibility and duration increased significantly in Group A [ （ 80.0% ± 17 % ） , （26.0 ± 5.9） min] after eight-week rapid pacing （ P 〈 0.05 ）. Conclusions This may be a good model for persistent atrial fibrillation research.