急性淋巴细胞白血病治疗前后血清sE-cad测定的临床意义

Clinical Significance of Determining Serum Level of Soluble Epithelia Cell Cadherin in the Treatment of Acute Lymphocyte Leukemia

为探讨急性淋巴细胞白血病(ALL)患者治疗前后血清可溶型上皮细胞钙粘蛋白(sE-cad)的水平变化与疗效的关系。使用酶联免疫吸附双抗体法(ELISA)测定ALL患者组、对照组血清sE-cad的水平。结果表明:ALL患者初治组血清sE-cad水平(83.98±22.62)ng/mL及未完全缓解组血清sE-cad水平(75.68±14.01)ng/mL明显高于对照组(25.74±7.79)ng/mL及完全缓解组(27.77±10.21)ng/mL,差异均有统计学意义(P<0.01);ALL患者血清sE-cad水平治疗达完全缓解后血清sE-cad水平较治疗前(84.26±22.49)ng/mL明显下降,差异有统计学意义(P<0.01),未完全缓解组治疗前后差异无统计学意义(P>0.05);ALL患者高白细胞血症组血清sE-cad水平(111.18±21.23)ng/mL明显高于非高白细胞血症组(75.32±15.11)ng/mL,差异有统计学意义(P<0.01);ALL患者治疗前后血清sE-cad水平与骨髓原始幼稚细胞百分数呈正相关关系,相关系数为0.687(P<0.01)。结论血清sE-cad水平与ALL患者疗效相关,检测sE-cad对ALL患者的预后判断和疗效观察有一定意义。

To explore the relationship of the serum level of soluble epithelial cell cadherin（sE-cad） and therapeutic efficacy before and after the treatment of acute lymphocyte leukemia.Methods：The serum levels of soluble epithelial cell cadherin in the acute lymphocyte leukemia group and the control group were measured by ELISA double antibody method.Results：The serum levels of sE-cad in non-treatment group and NR group were significantly higher than that in the control group and CR group（P0.01）.The serum level of sE-cad in the patients after treatment in CR group was significantly lower than that before treatment（P0.01）.The serum level of sE-cad in acute lymphocyte leukemia with high white blood cell viremia was significantly higher than that in non-high white blood cell viremia group（P0.01）.The serum level of sE-cad in acute lymphocyte leukemia was positively correlated with the percentage of marrow blasts,and the correlation coefficient was 0.687（P0.01）.Conclusion：The serum level of sE-cad is related to the therapy in acute lymphocyte leukemia,and the detection of sE-cad was of some significance to the prognosis and the clinical observation in acute lymphocyte leukemia.