射频消融术与^(125)I放射性粒子植入联合区域性灌注治疗胰腺癌疗效观察

Efficacy observation of radiofrequency ablation combined with ^(125)I radioactive seed implantation regional perfusion chemotherapy in the treatment of pancreatic cancer

目的探讨射频消融术与125I放射性粒子植入联合区域性灌注治疗胰腺癌的临床效果。方法将105例胰腺癌患者随机分为两组,对照组55例采用射频消融术治疗,观察组50例采用125I放射性粒子植入联合区域性灌注化学疗法治疗,比较两组的临床效果。结果术后观察组患者疼痛程度轻于对照组(P<0.01);术后所有患者均接受长期随访,对照组生存时间≤2年者35例(63.6%),3～4年者19例(34.5%),≥5年者1例(1.8%);观察组生存时间≤2年者17例(34.0%),3～4年者36例(72.0%),≥5年者7例(14.0%);观察组患者3～4年生存率高于对照组(P<0.01);5年以上生存率也高于对照组(P<0.05)。观察组患者并发症发生率低于对照组(P<0.05)。结论 125I放射性粒子植入联合区域性灌注化学疗法治疗胰腺癌效果明显,可提高患者生存率。

Objective To investigate the clinical effects of radiofrequency ablation combined with ^125Ⅰseeds implantation re-gional perfusion chemotherapy in the treatment of pancreatic cancer. Methods One hundred and five patients with pancreatic cancer were randomly divided into control group in which the patients received radiofrequency ablation treatment and observation group in which the patients received ^125Ⅰ radioactive seeds implantation regional infusion chemotherapy. The clinical effects of the patients in the two groups were compared. Results From the postoperative pain relief aspect, the patients in the observation group were better than that of the control group（ P 〈0. 01 ）. All the patients in the two groups received long term follow-up. In the control group, the survival time ≤2 years,3-4 years, ≥5 years were 63.6% ,34.5% and 1.8%, while in the observation group, the survival time≤2 years,3-4 years, ≥5 years were 34.0% ,72.0% and 14.0%. Three to four years survival rate of the patients in the observation group was higher than that of the patients of the control group（ P 〈0.01 ）, and so was with the five years survival rate（ P 〈0.05）. The complications incidence of the patients in the control group was higher than that of the observation group （ P 〈 0.05 ）. Conclusion ^125Ⅰ radioactive seeds implantation regional perfusion which has obvious efficacy can improve survival rate of patients.