摘要
异甘草酸镁是第4代甘草酸制剂,所含有效成分是单一构型的18α-甘草酸。药理及临床研究均表明,异甘草酸镁可安全有效地用于防治药物性肝损伤,发挥保肝护肝作用。综述近年来有关异甘草酸镁防治药物性肝损伤的药理作用和机制以及临床应用研究进展,并探讨其用于防治药物性肝损伤的优势。
Magnesium isoglycyrrhizinate（MgIG） is the fourth generation of glycyrrhizic acid preparation, in which the active component is 18α-glycyrrhizic acid as a single epimer. The pharmacological and clinical researches have demonstrated its hepatoprotective effects on drug-induced liver injury. The recent research progress on the pharmacological action, mechanism and clinical use of MgIG in the prevention and treatment of drug-induced liver injury was reviewed and its advantages in the prevention and treatment were discussed.
出处
《药学进展》
CAS
2013年第4期161-166,共6页
Progress in Pharmaceutical Sciences
关键词
异甘草酸镁
药物性肝损伤
保肝护肝
药理作用
作用机制
临床应用
magnesium isoglycyrrhizinate
drug-induced liver injury
hepatoprotective effect
pharmacological action
mechanism of action
clinical use
