TGF-β/Smad信号通路在腹膜纤维化发生、防治中的作用

TGF-β/Smad Signaling Pathway in the Preventing and Controlling of the Peritoneum Fibrosis

腹膜透析是治疗终末期肾衰竭有效的血液透析方法之一。而腹膜纤维化是腹膜透析患者终止腹膜透析治疗的重要原因之一。转化生长因子β1(TGF-β1)是促进腹膜纤维化的重要因子,在腹膜纤维化形成过程中,TGF-β1主要通过信号蛋白Smad2/3调节基因表达,进而促进细胞外基质的生成,促进纤维化的发生。该文主要就TGF-β/Smad信号通路与腹膜纤维化的关系,针对该通路防治腹膜纤维化进行综述。

Peritoneal dialysis is one of the effective treatments for end-stage renal failure. However,peritoneal fibrosis is an important reason of peritoneal dialysis patients abandoning the long-term peritoneal dialysis. TGF-β1 is the important factor causing peritoneal fibrosis. In the process of peritoneal fibrosis, TGF-β1 plays a role in regulating gene expression mainly through Smad2/3 signal protein ,which promotes the formaion of extracellular matrix, and aggravates the occurrence of fibrosis. Here is to make a review on the relationship between TGF-β/Smad signaling pathway and peritoneal fibrosis, the prevention and treatment of peritoneal fibrosis.