Ki-67抗原与肺癌关系的研究进展

Research Progress in Relationship between Ki-67 and Lung Cancer

细胞核相关抗原Ki-67是一种增殖细胞相关的核抗原,属于细胞核内的非组蛋白,在人类多种恶性肿瘤组织中存在过度表达,尤其是肺癌。Ki-67可反映非小细胞肺癌的发生、发展、转移,可作为其细胞增殖的标志之一。近年来研究发现,Ki-67虽不能很好地反映小细胞肺癌的生物学行为,但有助于其病理类型的判断。该文就Ki-67在肿瘤学方面,尤其是与不同类型肺癌间关系的相关研究予以综述。

Nuclei associated antigen （Ki-67）is a proliferating cell nucleus antigen. It is a non-histone proteins located within the cell nucleus, overexpressed in many human malignant tissues, especially in lung tissue. Ki-67 has become one of the tumor cell proliferation markers, which indicates the occurrence, development and metastasis of non-small cell lung cancer. Recent studies found that Ki-67 contribute to the judgment of the pathological type of small cell lung cancer,though it＇s not a good indication of its biological behavior. Here is to make a review on the Ki-67 research from oncology, especially focusing on its relationship with the different types of lung cancer.