OCT检测视网膜神经纤维层厚度在青光眼诊断中的应用进展

Application Progress in Diagnosis of Glaucoma by Retinal Nerve Fiber Layer Thickness Measurement with OCT

青光眼是一组具有特征性视神经损害和视野缺损的不可逆性致盲眼病,其病理损害基础是视网膜神经节细胞(RGC)及其轴索的损害。视网膜神经纤维层厚度(RNFL)反映了RGC轴突的数量,通过测量其厚度,可以在活体间接了解RGC的存活。光学相干断层扫描(OCT)是一种新的横截面成像技术,分辨率高,因而能对RNFL进行精确的测量。这个应用将在青光眼的诊断和随访中发挥重要的临床应用价值。

Glaucoma is a group of irreversible blind eye diseases with specific optic nerve damage and visual field defect. The pathological damage foundation is retinal ganglion cells （ RGC ） and its neuraxial damage. Retinal nerve fiber layer（RNFL） thickness reflects RGC axon number,therefore in vivo RGC survival can be known through measuring RNFL thickness. OCT is a new kind of cross section imaging technology with high resolution and can therefore accurately measure RNFL. This application will show great clinical value in the diagnosis and follow-up of glaucoma.