连钱草总黄酮缓释片的制备及体外释放度研究

Study on Preparation of Total Flavones in Glechoma longituba Sustained-release Tablets and Its in vitro Release

目的:研究连钱草总黄酮缓释片的制备工艺及体外释放特性。方法:采用三因素三水平正交试验设计,以释放度综合评分为评价指标,确定连钱草总黄酮缓释片的最佳制备工艺条件。并对优化的试验结果进行体外释放效果考察。结果:最优处方为羟丙基甲基纤维素(HPMC-K4M)和卡波姆934p二元骨架系统用量占片重30%,二者用量比为2∶1,乳糖为填充剂,用量为20%,5%PVP乙醇为黏合剂,湿法制备连钱草总黄酮缓释片。其体外释药机理符合零级释放。结论:制备的连钱草总黄酮缓释片缓释效果良好,制备工艺简单易行,值得广泛推广。

Objective：To study the preparation of total flavones in Glechoma longituba sustained-release tablets and evaluate its releasing features in vitro.Methods：Orthogonal experiment（L934） was used to optimize the process of preparation of total flavones in Glechoma longituba sustained-release tablets.Investigated the release effect in vitro of optimization test result.Results：The optimized prescription was HPMC-K4M and carbopol 934p account for 30% of the total tablet weight,their dosage ratio was 2∶ 1;Lactose as additives,20% dosage;5% PVP ethanol as adhesives,and compressed the wet granule of the materials into the total flavones in Glechoma longituba sustained-release tablets.The released profiles of the sustained-release tablets followed zero-order equation.Conclusion：The sustained-release effect of total flavones in Glechoma longituba sustained-release tablets is good,the preparation craft is easy and feasible and worth widely promoting.