分消清利汤治疗糖尿病胃肠功能障碍110例临床观察

Clinical observation on 100 cases of gastrointestinal dysfunction in diabetes treated with Fenxiaoqingli decoction

目的观察分消清利汤治疗糖尿病胃肠功能障碍的临床疗效。方法将205例糖尿病胃肠功能障碍患者随机分为2组。治疗组110例予分消清利汤口服治疗,对照组95例予西沙比利片口服治疗。2组均治疗1个月后观察疗效。结果治疗组总有效率85.4%,对照组总有效率68.4%,2组总有效率比较差异有统计学意义(P<0.05),治疗组疗效优于对照组。治疗组治疗后各症状积分均较本组治疗前显著降低(P<0.05,P<0.01),对照组治疗后除厌食、恶心、大便稀溏及营养不良外其他症状积分均较本组治疗前显著降低(P<0.05,P<0.01)。治疗组治疗后在改善食后饱胀、恶心、便秘、大便稀溏及营养不良方面优于对照组(P<0.05,P<0.01)。结论分消清利汤能明显改善糖尿病胃肠功能障碍患者的临床症状,促进胃肠蠕动,且不良反应较轻,疗效明显优于单纯西药治疗。

Objective To observe the therapeutic effect of Fenxiaoqingli decoction on gastrointestinal dysfunction in diabetes. Methods 205 cases of gastrointestinal dysfunction in diabetes were randomly divided into treatment and control groups. 110 patients in treatment group were treated with oral Fenxiaoqingli decoction. 95 cases in control group were treated with oral cisapride. The therapeutic efficacy of two groups was observed after 1 month. Resuits The total efficiency in treatment group was 85.4% ; total efficiency of control group was 68.4%. The total ef- ficiency of treatment group was higher than that of the control group （ P 〈 0. 05 ）. Each symptom scores after treatment were significantly reduced compared with those before treatment in the treatment group （ P 〈 0. 05, P 〈 0.01 ）. Each symptom scores except anorexia, nausea, loose stool and malnutrition after treatment were significantly reduced com- pared with those before treatment in the control group （ P 〈 0. 05, P 〈 0.01 ）. The improvement of fullness after eat- ing, nausea, constipation,loose stool and malnutrition in treatment group were superior to those in control group （ P 〈 0.05 ）. Conclusion Fenxiaoqingli decoction can significantly improve the clinical symptoms of diabetes gastrointestinal function disorder patients ,promote gastrointestinal motility, and less adverse reactions, its therapeutic effect was better than that of western medicine alone.