期刊文献+

TROP2在食管鳞状细胞癌中的表达及与临床病理的关系 被引量:1

下载PDF
导出
摘要 目的检测TROP2在食管鳞状细胞癌组织中的表达,探讨其与临床病理的关系。方法实时荧光定量PCR方法对50例食管鳞状细胞癌组织及癌旁正常组织TROP2的表达水平检测,分析其与临床病理资料的关系。结果 TROP2在癌组织中的表达显著高于癌旁正常组织(P<0.05);TROP2的高表达分别与食管癌的分化程度、浸润深度、淋巴结转移、TNM分期显著相关(P<0.05)。结论 TROP2的高表达与食管鳞状细胞癌临床病理密切相关。
出处 《齐齐哈尔医学院学报》 2013年第5期633-634,共2页 Journal of Qiqihar Medical University
  • 相关文献

参考文献9

  • 1Cheung WY, Liu G. Genetic variations in esophageal cancer risk and prognosis. Gastroenterol Clin North Am,2009,38( 1 ) :75-91.
  • 2Tsujikawa M, Kurahashi H, Tanaka T, et al. Identification of the gene responsible for gelatinous drop-like corneal dystrophy. Am J Hum Genet, 1998,63 : 1073-1077.
  • 3Huang E, Cheng SH, Dressman H, et al. Gene expression predictors of breast cancer outcomes. Lancet,2003,361 : 1590-1596.
  • 4Coldren CD, Helfrich BA, Witta SE, et al. Baseline gene expression predicts sensitivity to gefitinib in non-small cell lung cancer cell lines. Mol Cancer Res ,2006,4:521-528.
  • 5Ohmachi T, Tanaka F, biimori K, et al. Clinical significance of TROP2 expression in coloreetal cancer. Clin Cancer Res,2006,12: 3057-3063.
  • 6Birken kamp-Demtroder K, Olesen SH, Sorensen FB, et al. Differential gene expression in colon cancer of the caecum versus the sigmoid and rectosigmoid. Gut ,2005,54:374-384.
  • 7Nakashima K, Shimada H, Ochiai T, et al. Serological identification of TROP2 by recombinant cDNA expression cloning using sera of patients with esophageal squamous cell carcinoma. Int J Cancer, 2004,112 : 1029-1035.
  • 8Santin AD, Zhan F, Bellone S, et al. Gene expression profiles in primary ovarian serous papillary tumors and normal ovarian epithelium : identification of candidate molecular markers for ovarian cancer diagnosis and therapy. Int J Cancer,2004,112:14-25.
  • 9Iacobuzio-Donahue CA, Maitra A, Shen-Ong GL, et al. Discovery of novel tumor markers of pancreatic cancer using global gene expression technology. Am J Patho1,2002,160 : 1239-1049.

引证文献1

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部