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早发冠心病患者合并非乙醇性脂肪性肝病的发生率及危险因素 被引量:6

Prevalence of non-alcoholic fatty liver disease in premature coronary heart disease and risk factor
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摘要 目的 :探讨早发冠心病患者非乙醇性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)的患病率和危险因素。方法:冠状动脉造影诊断为早发冠心病的748例患者,入院期间进行空腹肝胆超声检查。结果:NAFLD患者发生率为49.6%(371/748)。NAFLD组糖尿病,血清总胆固醇,三酰甘油,血清丙氨酸转氨酶及天冬氨酸转氨酶高于非NAFLD组,差异有统计学意义(P<0.05)。NAFLD组多支病变比率明显高于非NAFLF组(χ2=4.455,P=0.04)。多因素Logistic回归分析中,只有糖尿病和冠心病左主干病变是NAFLD的危险因素。结论:早发冠心病患者中NAFLD发生率高达50%,其中冠状动脉多支病变和糖尿病与NAFLD的发生密切相关。 Objective: The aim of this study was to investigate the incidence and risk factor of non-alcoholic fatty liver disease NAFLD in premature coronary artery disease in patients undergoing coronary angiogram.Methods: 748 patients with premature coronary artery disease who underwent coronary angiogram were enrolled into this study.All patients had ultrasound screening for fatty liver.Results: Among 748 recruited patients,341(49.6%)had fatty liver by ultrasonography.Incidence of NAFLD in the patients in multi-vessel disease was higher than those of 1-vessel disease(χ2=4.455,P=0.04).By multivariable logistic regression analysis,diabetes mellitus,stenosis of left main stem were risk factor in NAFLD patients with premature coronary heart disease.Conclusion: Incidence of NAFLD was about 50% in premature coronary artery disease patients.The presence of NAFLD is associated with multi-vessel disease and diabetes mellitus.
出处 《心肺血管病杂志》 CAS 2013年第2期158-161,共4页 Journal of Cardiovascular and Pulmonary Diseases
关键词 冠心病 非酒精性脂肪性肝病 超声 早发 Coronary heart disease Non-alcoholic fatty liver disease Ultrasound Premature
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  • 1Xiao-LanLu Jin-YanLuo MingTao YanGen PingZhao Hong-LiZhao Xiao-DongZhang NeiDong.Risk factors for alcoholic liver disease in China[J].World Journal of Gastroenterology,2004,10(16):2423-2426. 被引量:17
  • 2范建高,郑晓英,张梅,杨兆瑞.非酒精性脂肪性肝病大鼠肝窦超微结构及微血栓观察[J].肝脏,2005,10(1):41-42. 被引量:18
  • 3Fatty Liver and Alcoholic Liver Disease Study Group of the Chinese Liver Disease Association..非酒精性脂肪性肝病诊疗指南[J].中华肝脏病杂志,2006,14(3):161-163. 被引量:1513
  • 4Fatty Liver and Alcoholic Liver Disease Study Group of the Chinese Liver Disease Association..酒精性肝病诊疗指南[J].中华肝脏病杂志,2006,14(3):164-166. 被引量:271
  • 5T saiM Y.L aboratory assessment of mild hyperhomocysteinemia as an independent risk factor for occlusive vascular diseases.Clin Chem,1996,42:492-493.
  • 6Angulo P.Nonalcoholic fatty liver disease.N Engl J Med,2002,346:1221-1231.
  • 7Day C,Saksena S.Nonalcoholic steatohepatitis:definitions and pathogensh.J Gastroenterol Hepatol,2002,17:377-384.
  • 8Knobler H,Schattner A,Zhornicki T,et al.Fatty liver-an additional and treatable feature of the insulin resistance syndrome.Q J Med,1999,92:73-79.
  • 9朱红霞 朱筠 张明琛 等.维吾尔族和汉族2型糖尿病合并非酒精性脂肪肝患者的代谢特征及相关危险因素探讨.中国全科医学,2009,12(7):1164-1164.
  • 10Farre11 GC, George J, Pauline de la M, et al. Fatty liver disease: NASH and related disorders [ M ]. Oxford: Blackwell Publishing, 2005 : 1 - 22.

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  • 1王志兴.辛伐他汀与瑞舒伐他汀对心肌梗死患者PCI后血浆NT-proBNP、MMP-2表达及左室重构作用比较[J].湖北医药学院学报,2011,30(4):394-396. 被引量:6
  • 2Masahide Hamaguchi,Takao Kojima,Noriyuki Takeda,Chisato Nagata,Jun Takeda,Hiroshi Sarui,Yutaka Kawahito,Naohisa Yoshida,Atsushi Suetsugu,Takahiro Kato,Junichi Okuda,Kazunori Ida,Toshikazu Yoshikawa.Nonalcoholic fatty liver disease is a novel predictor of cardiovascular disease[J].World Journal of Gastroenterology,2007,13(10):1579-1584. 被引量:56
  • 3Labarbera M, Milechman G, Dullbeeco F. Premature coronary artery disease in a patient with glycogen storage disease [ J ]. J Invasive Cardiol, 2010,22 ( 8 ) : 156 -158.
  • 4Zhang Guo-chun, Feng Shan-guo. Study on the coronary features and risk factors of male patients with premature coronary heart disease [ J]. Chin J Misdiagn ,2011,7 ( 11 ) :2481-2482.
  • 5Dirisamer A, Stadler A, Bucek RA, et al. ApoB-100 and ApoB/ ApoA-1 ratio in children and adolescents from families with very early myocardial infarction [ J ]. Acta Paediatrica, 2006,95 ( 7 ) : 810-813.
  • 6中华人民共和国卫生部.WS319-2010冠状动脉粥样硬化性心脏病诊断标准[S].2010.
  • 7Natarajan P, Ray KK, Cannon CP. High-density lipopretein and coronary heart disease: current and future therapies [ J ]. J Am Coll Cardiol,2010,55(13) :1283-1299.
  • 8Schaefer EJ, Anthanont P, Asztalos BF. High-density lipoprotein metabolism, composition, function, and deficiency [ J ]. Curt Opin Lipido1,2014 ,25 ( 3 ) : 194-199.
  • 9Lima LM, Carvalho MG, Sabino Ade P, et al. ApoB/ApoA1 ratio in central and peripheral arterial diseases [ J ]. Arq Bras Endocrinol Metabol,2007,51 (7) : 1160-1165.
  • 10Walldius G, Jungner I, Aastveit AH, et al. The apoB/apoA1 Ratio is better than the cholesterol ratios to estimate the balance between the plasma proatherogenic and anfiatherogenic lipoproteins and predict coronary risk [ J ]. Clin Chem Lab Med, 2004,42 (12) :1355.

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