布拉氏酵母菌治疗新生儿黄疸的临床疗效观察

Clinical Efficacy of Saccharomyces Boulardii Sachets in Patients with Neonatal Jaundice

目的:观察布拉氏酵母菌治疗新生儿黄疸的临床疗效。方法:将70例新生儿黄疸患儿随机分为观察组(35例)和对照组(35例),对照组给予常规治疗,观察组在常规治疗基础上加用布拉氏酵母菌250mg/次,1次/d,口服。结果:两组患儿治疗前、后,观察组和对照组的血清胆红素水平的差异均无统计学意义(P>0.05),但日均下降值以及住院天数两项指标观察组均好于对照组(P<0.05)。结论:加用布拉氏酵母菌较常规治疗能够明显加快血清胆红素的下降速度,缩短住院天数,疗效显著,且未发现不良反应,适于临床推广使用。

Objective：To investigate the clinical efficacy of saccharomyces boulardii sachets in patients with neonatal jaundice. Methods. 70 cases were divided randomly into controlled group （35 cases） and experimental group（35 cases）.Patients in controlled group received routine medical therapy. While patients in experimental group received saccharomyces boulardii sachets 250mg, qd, for oral administration and conventional medical therapy. Results： No statistical difference was found in serum levels of bilirubin between controlled and experimental group before and after treatment （P〉O. 05）, but serum levels of bilirubin daily and days of hospitalization were decreased significantly in experimental group than that in controlled group （P〈 0. 05）. Condusion： Additional saccharomyces boulardii sachets into routine medical therapy may improve the serum of bilirubin in decreasing speed, reduce the days of hospitalization, no side effect had been observed, it is worth boosting and using in clinical.