肺炎支原体感染患儿血清中IL-8和TNF-α的变化情况探讨

Study on changes of serum IL-8 and TNF-α in children with Mycoplasma pneumoniae infection

目的:探讨肺炎支原体感染患儿血清中IL-8和TNF-α的变化情况。方法:回顾性分析2011年1月～2012年9月于吉林大学第二医院住院的具有完整资料的肺炎支原体肺炎患儿60例,采用ELISA检测患儿血清中IL-8和TNF-α的水平,并与60例健康儿童的检测结果进行分析比较。结果:观察组患儿血清IL-8和TNF-α的水平显著高于对照组,差异有统计学意义(P<0.05)。结论:IL-8和TNF-α能反应肺炎支原体感染的严重程度,可作为诊断和治疗的参考指标。

Objective ： To explore the changes of serum interleukin - 8 （ IL - 8 ） and tumor necrosis factor - a （ TNF - cx） in chil- dren with Mycoplasma pneumoniae （MP） infection. Methods： The clinical data of sixty patients with MP pneumonia who were treated in the hospital from January 2011 to November 2012 were analyzed retrospectively, ELISA was used to detect the serum levels of IL -8 and TNF - ct, then the results were compared with those of 60 healthy children. Results ： The serum levels of IL - 8 and TNF - a in observation group were statistically significantly higher than those in control group （ P 〈 0. 05 ） . Conclusion ： IL - 8 and TNF - a can reflect the degree of se- verity of MP infection, which can be used as reference indexes for diagnosis and treatment of MP infection.