IgM并发IgG抗-E抗体引起交叉配血不合1例

A case report of blood cross-matching incompatibility caused by combining IgM and IgG antibodies against E antigen

抗-E抗体是Rh系统中最常见的抗体之一,可以天然产生,但常常是通过输血、妊娠等免疫刺激而产生。近日我们为一老年男性长期输血患者进行抗体鉴定,发现其血清中同时存在IgM和IgG抗-E抗体,现报告如下。1对象与方法1.1病例介绍患者,男,76岁,就诊于上海市某医院,有多次输血史,因交叉配血时发现不规则抗体阳性,送至上海市血液中心做进一步鉴定。

We analyzed a case of an elderly patient who presented with incompatibility reactions in multiple transfusions. Using quick centrifugation, classic anti-human globulin and polybrene method in erythrocyte spectrum, we identified that both IgM and IgG anti-E antibodies were present in the patient ＇s serum. We selected the same ABO type, E-antigen negative red blood cell suspension for him, which showed no agglutination and hemolysis in the cross-matching tests. Our study suggested that for patients with only anti-E antibodies in the serum, same ABO type,E-antigen negative red blood cell suspension could be used for transfusion.