血清学指标检测对类风湿关节炎的诊断意义

Diagnosis significance of serology index detection in rheumatoid arthritis

类风湿关节炎（rheumatoidarthritis，RA）是一种以慢性破坏性关节病变为特征的全身性自身免疫病“’。具有高发性、高致残性等特点，其病理特征为慢性滑膜炎，发病2年内即可发生不可逆性的关节损害，严重影响人们的生活质量，早期诊断和治疗是减少和阻止病情发展及防止致残的关键。因此，在临床中要有高敏感性、高特异性的实验室检测指标和诊断方法，有助于评价疾病的活动性及预后，为RA的早期诊断提供可靠依据。RA患者体内存在多种自身抗体、细胞因子及相关蛋白，现就上述相关血清学检i贝4指标综述如下。

Rheumatoid arthritis （RA） is a common systemic autoimmune diseases, which is lack of specific diagnostic and treatment currently, especially for early diagnosis and atypical cases are easy to misdiagnosis and wrong treatment. In recent years, immunology and molecular biology have been continuous improved. New markers such as osteopontin（OPN）, anti-keratin antibodies （AKA）, anti-SA antibodies, poly anti-fiber protein antibody （AFA） ,anti-perinuclear factor antibodies （APF） and anti-CCP antibodies were found which would improve RA diagnostic sensitivity and specificity. These detection of serology indexes combination could help to improve the early diagnosis of RA.