醒脑静注射液对急性感染性发热干预作用的临床研究

Effect of Xingnaojing Injection Intervention in Acute Infective Fever

目的:探讨醒脑静注射液对感染性发热的干预作用。方法:将210例急性感染性发热患者按感染的判定标准分为病毒组115例与细菌组95例,病毒组随机分为治疗A组65例和对照A组50例;细菌组分为治疗B组52例和对照B组43例。对照组常规治疗,治疗组加用醒脑静治疗。比较各组体温变化、醒脑静注射液对发热的干预。结果:治疗A组用药后2 h、4 h的退热效果、退热时间(4.3±2.7)h、发热次数(3.0±1.4)次、疗程(3.8±1.6)d均显著优于对照A组(P<0.01);治疗B组4h的退热效果和退热时间(6.5±3.3)h明显优于对照B组(P<0.05);但发热次数(5.5±1.8)次和疗程(7.3±2.4)d无明显改善(P>0.05)。结论:醒脑静注射液对病毒感染性发热退热有效、迅速,减少再发热,有效缩短病程,能明显干预病毒感染所致的发热过程。

Objective： To explore the effect of Xingnaojing injection intervention in infective fever. Methods： 210 patients with acute infective fever were divided into viral infection group （n=115） and bacterial infection group （n=95）. Viral infection group was divided into treatment group A （n=65） and control group （n=50）. Bacterial infection group was divided into treatment group B （n=52） and control group （n=43）. The control groups were treated by routine measurement, while the treatment groups were treated by Xingnaojing injection based on the control groups. The changes of temperature and the intervention of Xingnaojing were compared in different groups. Results： After 2h, 4h of treatment, the antipyretic effect,defervescence time （4.3±2.7）h, times of fever（3.0_±1.4）, course of treatment （3.8±1.6）d in treatment group A were significantly better than those in control group A （P 〈 0.01）,the antipyretic effect and defervescence time （6.5±3.3）h in treatment group B were better than those in control subgroup B （P 〈 0.05）, but the times of fever（5.5±1.8） and course of treatment（7.3±2.4）d were not improved obviously（P 〉 0.05）. Conclusions： Xingnaojing injection can depress the fever induced by viral infection effectively and rapidly, reduce the course of treatment and interfere the course of fever induced by viral infection.