摘要
目的观察静脉注射吗啡在重度癌痛治疗中的有效性及安全性。方法对48例住院的重度癌痛患者给予吗啡静脉注射,采用数字评价量表(numerical rating scale,NRS)每15分钟对疼痛程度进行评估,根据评分结果调整吗啡剂量,观察镇痛效果及不良反应。结果所有病例在注射三个周期后疼痛降至轻度疼痛或无痛,平均时间45分钟,未见明显的不良反应,24小时内癌痛控制有效率达到100%;在观察的时间内(24小时),不良反应有头晕(3例)、恶心、呕吐(5例),经对症治疗后缓解。结论静脉应用吗啡在重度癌痛的治疗中,能迅速缓解疼痛症状,降低NRS评分,提高患者生活质量,副反应少且可控制,是重度癌痛治疗的首选治疗方法。
Objective To study the efficacy and safety of intravenous injection of morphine in the patients with severe cancer pain. Method 48 patients who suffered severe cancer pain receive rapid titration by intravenous injection of mor- phine. The efficacy （NRS） was assessed every 15 minutes to determine subsequent dose, and side-effects were observed. Result After 3 cycle injections, the pain score of all the 48 patients were decreased to 0-3, and there were no obvious side-effects. The efficiency was 100% in the first 24h; during the injection, 3 patients felt dizzy, 5 patients developed nausea and vomited, and all the side-effects relieved after symptomatic treatment. Conclusion Intravenous injection of morphine in the treatment of severe cancer pain can quickly relieve the pain, decrease the pain score, improve the quality of life with few but controllable side-effects, and could be the first choice in clinical cancer pain management.
出处
《癌症进展》
2013年第2期168-171,共4页
Oncology Progress
基金
江门市科技局科研项目(2012002)
关键词
吗啡
重度癌痛
静脉注射
Morphine
severe cancer pain
intravenous injection
