雷米普利与非洛地平对高血压拌左室肥厚患者疗效的对比研究

Comparison of the effects bewteen ramipril and felodipine in patients with hypertensive left ventricular hypertrophy

目的比较雷米普利与非洛地平对高血压患者左室肥厚的疗效。方法 93例高血压拌左室肥厚患者随机接受雷米普利(47例,雷米普利组)或非洛地平(46例,非洛地平组)治疗,随访治疗6个月后复查左室重量和左室重量指数。结果用药后两组高血压患者左室重量和左室重量指数均显示有意义的减少[雷米普利组LVM:(244.3±5.4)g和(207.7±3.5)g,LVMI:(131±5)g/m2和(114±4)g/m2,P均﹤0.01;非洛地平组LVM:(250.0±4.2)g和(237.5±4.2)g,LVMI:(136±4)g/m2和(131±3)g/m2,P均﹤0.05];与非洛地平组比较,雷米普利组左室重量和左室重量指数降低更明显[LVM:(244.3±5.4)g和(237.5±4.2)g;LVMI:(131±5)g/m2和(131±3)g/m2,P均﹤0.01]。结论雷米普利能够逆转高血压患者的左室肥厚,且优于非洛地平。

Objective To compare the effects of ramipril and felodipine in patients with hypertensive left ventricular hypertrophy. Methods 93 patients with hypertensive were randommized to receive ramipril （Group A, 47 cases）and felodipine（Group B, 46 cases）. The left ventricular mass （LVM）and the left ventricular mass index（LVMI）after 6 months of treatment were compared between the two groups. Results In group A, the LVM and the LVMI were significantly decreasedP0.01], in group B, the LVM and LVMI were significantly decreased P0.05]at 6 months later. Compared with groupB, the LVM and the LVMI of group A were much lowerP0.01],Conclusion Ramipril may exert a better effect than felodipine in patients with hypertensive left ventrcular hypertrophy.