期刊文献+

吉西他滨单独或联合方案治疗复发难治性NK/T细胞淋巴瘤的效果观察 被引量:3

原文传递
导出
摘要 目的分析吉西他滨单独或联合方案治疗复发难治性NK/T细胞淋巴瘤的疗效。方法通过回顾性调查的方式收集2009年1月至2012年1月采用吉西他滨单独或联合方案治疗的20例已接受其他化疗方案治疗并出现病情恶化的复发难治性NK/T细胞淋巴瘤患者的临床资料,通过分析患者的无进展生存期(PFS)和总生存期(OS)评价吉西他滨的治疗效果。结果20例患者接受吉西他滨治疗后显效8例(40%),其中完全缓解4例,部分缓解4例;20例患者的中位PFS和OS分别为2.2、3.4个月,其中8例显效患者的中位PFS为6.8个月,OS因为还有患者存活不能确切计算。结论吉西他滨治疗复发难治性NK/T细胞淋巴瘤效果较好,是L-天冬酰胺酶类化疗方案治疗失败后很好的补救方案。
作者 李学雷
出处 《中国医师进修杂志》 2013年第10期46-48,共3页 Chinese Journal of Postgraduates of Medicine
  • 相关文献

参考文献10

  • 1Au WY, Weisenburger DD, Intragumtornchai T, et al. Clinical differences between nasal and extranasal natural killer/T-celllymphoma: a study of 136 cases from the International Peripheral T-CeU Lymphoma Project. Blood, 2009, 113 ( 17 ) : 3931-3937.
  • 2Suzuki R, Suzumiya J, Yamaguchi M, et al. Prognostic factors for mature natural killer (NK) cell neoplasms: aggressive NK cell leukemia and extranodal NK cell lymphoma, nasal type. Ann Oncol, 2010, 21(5): 1032-1040.
  • 3Kim SJ, Kim K, Kim BS, et al. Phase trial of concurrent radiation and weekly cisplatin followed by VIPD chemotherapy in newly diagnosed, stage ] E to II E, nasal, extranedal NK/T-Cell lymphoma: Consortium for Improving Survival of Lymphoma study. J Clin Oncol, 2009, 27(35 ) : 6027-6032.
  • 4Yamaguchi M, Tobinai K, Oguchi M, et al. Phase I / II study of concurrent chemoradiotherapy for localized nasal natural killer/T- cell lymphoma: Japan Clinical Oncology Group Study JCOG0211. J Clin Oncal, 2009, 27(33):5594-5600.
  • 5Cheson BD, Pfistner B, Juweid ME, et al. Revised response criteria for mali~ant lymphoma. J Clin Oncol, 2007, 25 (5) : 579- 586.
  • 6Yamaguchi M, Kwong YL, Kim WS, et al. Phase lI study of SMILEchemotherapy for newly diagnosed stage IV, relapsed, or refractory extranedal natural killer (NK)/T-cell lymphoma, nasal type: the NK-Cell Tumor Study Group study. J Clin Oncol, 2011, 29 (33) : 4410-4416.
  • 7Jaccard A, Gachard N, Marin B, et al. Efficacy of L-asparaginase with methotrexate and dexamethasone (AspaMetDex regimen) in patients with refractory or relapsing extranodal NK/T-cell lymphoma, a phase 2 study. Blood, 2011, 117(6) : 1834-1839.
  • 8宋堃,李滨,孙维佳.吉西他滨单药与以其为基础的联合化疗治疗进展期胰腺癌疗效的meta分析[J].中华外科杂志,2011,49(9):839-842. 被引量:3
  • 9宋海平,王颂平,孙翠萍,邱文生,梁军.多西他赛及吉西他滨分别联合顺铂治疗晚期非小细胞肺癌随机对照临床研究[J].中国癌症杂志,2008,18(7):531-534. 被引量:49
  • 10Zinzani PL, Venturini F, Stefoni V,et al. Gemcitabine as single agent in pretreated T-cell lymphoma patients: evaluation of the long-term outcome. Ann Oncol, 2010, 21 (4) : 860-863.

二级参考文献30

  • 1倪秉洁.GP方案治疗中晚期非小细胞肺癌的疗效观察[J].癌症进展,2005,3(3):276-278. 被引量:11
  • 2陈颖波,陈嘉,陈凌翔,蔡炜宇,黄富麟.多西他赛联合顺铂三周方案与每周方案治疗非小细胞肺癌[J].中国癌症杂志,2005,15(2):169-170. 被引量:25
  • 3李峻岭,张湘茹,刘基巍,陈中元,林英城,王远东,陈强,南克俊,宋恕平,韩福才,朱允中,李龙芸,郑玉红,储大同.泰索帝每周给药联合顺铂一线治疗晚期非小细胞肺癌的临床研究[J].中华肿瘤杂志,2006,28(4):309-312. 被引量:24
  • 4崔成旭,张湘茹,朱允中,杨树军,张祥福,徐光川,黄诚,刘端琪,郑玉红,储大同.多西他赛联合异环磷酰胺方案与多西他赛单药方案二线治疗晚期非小细胞肺癌[J].中国癌症杂志,2006,16(10):855-858. 被引量:22
  • 5Jemal A,Siegel R,Ward E,et al.Cancer statistics,2008.CA Cancer J Clin,2008,58:71-96.
  • 6Renouf D,Moore M.Evolution of systemic therapy for advanced pancreatic cancer.Expert Rev Anticancer Ther,2010,10:529-540.
  • 7Jadad AR,Moore RA,Carroll D,et al.Assessing the quality of reports of randomized clinical trials:is blinding necessary? Control Clin Trials,1996,17:1-12.
  • 8Colucci G,Giuliani F,Gebbia V,et al.Gemcitabine alone or with cisplatin for the treatment of patients with locally advanced and/or metastatic pancreatic carcinoma:a prospective,randomized phase Ⅲ study of the Gruppo Oncologia dell'Italia Meridionale.Cancer,2002,94:902-910.
  • 9Berlin JD,Catalno P,Thomas JP,et al.Phase Ⅲ study of gemcitabine in combination with fluorouracil versus gemcitabine alone in patients with advanced pancreatic carcinoma:Eastern Cooperative Oncology Group Trial E2297.J Clin Oncol,2002,20:3270-3275.
  • 10Rocha Lima CM,Green MR,Rotche R,et al.Irinotecan plus gemcitabine results in no survival advantage compared with gemcitabine monotherapy in patients with locally advanced or metastatic pancreatic cancer despite increased tumor response rate.J Clin Oncol,2004,22:3776-3783.

共引文献50

同被引文献13

  • 1张之南,郝玉书,赵永强,等.血液病学[M].北京:人民卫生出版社,2011:1273.
  • 2Kohrt H, Advani R. Extranodal natural killer/T-cell lymphoma: cur- rent concepts in biology and treatment[ J]. Leuk Lymphoma,2009, 50 ( 11 ) : 1773 - 1784.
  • 3Lee KW, Yun T, Kim DW, et al. First-line ifosfamide, methotrexate, etoposide and prednisolone chemotherapy +/-radiotherapy is active in stage I /II extranodal NK/T cell lymphoma[ J]. Leuk Lympho- ma,2006,47 (7) :1274 - 1282.
  • 4Yong WB, Zheng W, Zhu J, et al. L-asparaginase in the treatment of refractory and relapsed extranodal NK/T-eelI lymphoma, nasal type [J]. Ann Hematol,2009,88 (7) :647 - 652.
  • 5Jaccard A, Gachard N, Marin B, et al. Efficacy of L-asparaginage with methotrexate and dexamethasone( AspaMetDex reginmen)in pa- tients with refractory or relapsing extranodal NK/T-cell lymphoma, a phase 2 study[J]. Blood,2011,117(6) :1834 - 1839.
  • 6Shen L, Au WY, Guo T et al. Proteasome in hibitor borte zomib-in- duced apoptosis in natural killer(NK) -cell leukemia and lymphoma: an in ivtro and in vivo preclinical evaluation[J]. Blood,2007,110 ( 1 ) :469 - 470.
  • 7Beljaards RC,Kandewitz P,Berti E,et al. Primary cutaneous CD30 positive large ceU lymphoma: definition of new type of cutaneous lymphoma with a favorable prognosis. A European Muhicenter Study of 47 patients[ J]. Cancer, 1993,71 (6) :2097 - 2104.
  • 8周颖,蔡清清,林旭滨,高岩,卜庆,王潇潇,黄慧强.SMILE方案治疗复发难治NK/T细胞淋巴瘤的初步临床报告[J].白血病.淋巴瘤,2009,18(4):213-215. 被引量:15
  • 9潘耀柱,白海,王存邦,王璇,徐淑芬,张茜,葸瑞,周进茂,陈燕,王晓靖.改良VDLP方案治疗难治复发NK/T细胞淋巴瘤13例[J].白血病.淋巴瘤,2011,20(4):240-241. 被引量:4
  • 10牛政权,王侃,于洁,李金红,刘辉.原发性皮肤NK/T细胞淋巴瘤2例报告[J].中国临床研究,2014,27(5):639-640. 被引量:1

引证文献3

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部