CD44v6、ICAM-1及E-cadherin在子宫内膜异位症中的表达及意义

Expression and significance of CD44v6,ICAM-1 and E-cadherin in endometriosis

目的探讨黏附分子CD44异构体6(CD44v6)、细胞间黏附分子-1(ICAM-1)和细胞钙黏附素E(E-cadherin)在子宫内膜异位症(EMs)发生、发展中的作用。方法通过免疫组化方法分别检测CD44v6、ICAM-1和E-cadherin在子宫内膜异位症患者在位内膜、异位内膜和正常子宫内膜中的表达。结果 EMs患者中异位内膜CD44v6表达明显高于在位内膜和正常内膜(P<0.05);异位内膜中ICAM-1表达高于在位内膜(P<0.05),且其在位内膜高于正常内膜(P<0.05);异位内膜及在位内膜中E-cadherin表达显著低于正常内膜(P<0.05)。结论子宫内膜异位症异位内膜、在位内膜中CD44v6、ICAM-1的高表达和E-cadherin的低表达在子宫内膜异位症的发生、发展中起重要作用。

Objective To investigate the role of CD44v6,ICAM-1 and E-cadherin in development of endmetriosis（EMs）.Methods Immunohistochemical method was used to detect the expression of CD44v6,ICAM-1 and E-cadherin in the EMs eutopic,ectopic endometrium and normal endometrium.Results CD44v6 expression in ectopic endometrium was significantly higher than that in the eutopic endometrium and the normal endometrium（P0.05）.ICAM-1 expression in the ectopic endometrium was higher than that in the eutopic endometrium,and ICAM-1 expression in the eutopic endometrium was higher than that in the normal endometrium（P0.05）.E-cadherin expression in the ectopic endometrium and the eutopic endometrium decreased significantly than that in the normal endometrium（P0.05）.Conclusion Higher expression of CD44v6 and ICAM-1 and lower expression of E-cadherin in ectopic and eutopic endometrium of EMs play an important role in the development of EMs.