阿托伐他汀与辛伐他汀在颈动脉粥样硬化治疗中的比较

Comparison of atorvastatin and simvastatin in the treatment of patients with carotid atherosclerosis

目的探讨阿托伐他汀与辛伐他汀在预防颈动脉粥样硬化患者发生脑梗死中的作用以及对肝功能的影响。方法将160例颈动脉粥样硬化患者随机分为两组,分别给予阿托伐他汀与辛伐他汀治疗,阿托伐组给予阿托伐他汀钙片20 mg/晚,辛伐他汀组给予辛伐他汀钠片40 mg/晚,观察使用不同他汀治疗时脑梗死和肝功能异常发生率的情况。结果辛伐他汀与阿托伐他汀治疗1年中脑梗死发生率比较差异有统计学意义(χ2=4.74,P<0.05),1年内肝功能异常发生率比较差异有统计学意义(χ2=4.10,P<0.05)。结论辛伐他汀与阿托伐他汀比较具有较强稳定颈动脉粥样硬化斑块的作用,减少了脑梗死的发生,而且在长期发挥治疗作用的同时,肝功能出现异常的发生率要低于阿托伐他汀。

Objective To investigate the preventive effect of atorvastain and simvastatin on cerebral infarction in patients with carotid atherosclerosis,and to compare the effect on liver function.Methods One hundred and sixty cases of carotid atherosclerosis were randomly divided into two groups,they were given different statins therapy.Atorvastatin group were given atorvastatin calcium 20 mg per night,and simvastatin group were given simvastatin tablets 40 mg per night.The incidences of cerebral infarction and abnormal liver function by using atorvastatin or simvastatin were observed.Results During 1 year treatment,the incidence of cerebral imfarction（χ2=4.74,P0.05） and abormal liver function（χ2=4.10,P0.05） had statistical significance difference between atorvastatin group and simvastatin group.Conclusion Compare with atorvastatin,simvastatin has a stronger stabilization of carotid plaque,it should decrease the incidence of cerebral infarction and abnormal liver function.