复发性流产的病因分析及治疗新进展

Progress of diagnosis and treatment of recurrent miscarriage

尽管复发性流产只影响了约1%～5%的育龄夫妇,但是它却极大的影响了患者的家庭幸福和心理状态。目前已知的危险因素包括遗传异常、解剖结构畸形、感染性疾病、内分泌失调、免疫因素和获得性或遗传性血栓形成倾向以及环境因素。近年,新的危险因素逐渐被人们认识,但仍有50%以上的患者病因未明。目前的治疗方法主要包括手术干预、胚胎植入前基因诊断、激素治疗、抗凝疗法和免疫调节治疗。本研究将对当前的病因和治疗新进展进行综述。

Although recurrent miscarriage（RM）affects 1%-3% of couples during childbearing years worldwide,it has a major influence on the wellbeing and psychosocial status of patients.So far,possible risk factors include genetic anomalies,anatomical malformations,infectious diseases,endocrine dysfunctions,（auto）immune disorders,acquired and inherited thrombophilia as well as environment factors.Other possible new risk factors for RM were gradually realized by us.But more than 50% of the cause is still unknown.So far,treatment strategies and options consist of surgical interventions,preimplantation genetic diagnosis（PGD）,hormonal treatment and anticoagulant as well as immunomodulatory medication.This review will summarize the established and new diagnostic and therapeutic options of RM.