磺苄西林、舒他西林、美洛西林、替卡西林的太赫兹指纹谱

Terahertz fingerprint spectra of sulbenicillin, sultamicillin, mezlocillin, and ticarcillin

以一类常用的抗生素-青霉素类抗生素作为研究对象,选取4种具有代表性的药品磺苄西林、舒他西林、美洛西林、替卡西林,基于太赫兹时域光谱(THz-TDS)技术,进行实验研究。通过光谱实验及理论分析,获取药品的太赫兹时域光谱,结合傅里叶变换,获得频域光谱及太赫兹吸收系数曲线。结果表明,4种药品在0.40～1.60 THz波段存在明显不同的吸收特征。因此,太赫兹光谱技术十分适合检测抗生素这种化学结构有微小不同的药品,并且可以清晰通过吸收峰的位置分辨出抗生素药类的种类。为国家食品药品监督管理提供一种新的可靠的检测技术,且可以以数据库的形式为药品的鉴定提供标准。

Terahertz time-domain spectroscopy （THz-TDS） technique is a new teclanology mat can oe useo for non-destructive testing （NDT）, research of molecular dynamics, the nature of crystal, structure and conformation of biological molecules etc. In this work, based on THz-TDS technique, antibiotics of four representative penicillin antibiotic drugs （sulbenicillin sultamicillin, mezlocillin, ticarcillin） were investigated. THz spectral features of antibiotics were studied with the method of both experimental measurement and theoretical analysis. This material was identified through testing the absorption and index of refractive. The experimental results show that the absorption spectra of the four antibiotics between 0.40-1.60 THz are obviously different, which are therefore the fingerprints of them. The research indicates that THz-TDS technique is very suitable for the detection of antibiotics which have slight difference in chemical structure, and the antibiotic medicine can be distinguished clearly by their THz fingerprint spectra.