摘要
在微波无溶剂辐射条件下,以硫代-4-色满酮和取代氨基硫脲为原料,通过中性Al2O3催化,设计并高产率的合成了标题化合物,其结构经1HNMR、IR、ESI-MS和元素分析表征。相较于传统方法,微波干法大大缩短反应时间,极大程度提高产率,是一种绿色友好的合成方法。通过抗菌活性测试对其抑菌效果进行研究,结果表明,目标物对所试的部分菌种具有较强的抑制作用。
Ten novel thiosemicarbazones derivatives of 2,3-dihydrothiochromen-4-one have been designed and synthesized from 2,3-dihydrothiochromen-4-one and thiosemicarbazide by microwave irradiation under solvent-free conditions.Their structures were confirmed by 1HNMR,IR,MS and elemental analysis.Compared with traditional method,the methodology has some advantages,such as fast reaction rate,high yield and friendly to environment.Antibacterial test indicated that some of target compounds have good antibacterial activity against E.coli.
出处
《化学试剂》
CAS
CSCD
北大核心
2013年第4期300-304,共5页
Chemical Reagents
基金
西南民族大学中央高校基本科研业务费专项资助项目(12ZYXS78)
四川省科技厅资助项目(2011JY035)
国家外专局外国文教专家资助项目(2012-29)
关键词
缩氨基硫脲
硫代-4-色满酮
合成
微波辐射
抗菌活性
thiosemicarbazone
2
3-dihydrothiochromen-4-one
synthesis
microwave irradiation
antibacterial activity
