共晶法在天然植物成分的提取纯化中的应用--以大黄酸为例

Application of an Effective Cocrystal Method in Chinese Medicinal Plant Components Preparative Isolation and Purification——Preparative Isolation and Purification of Rhein by Cocrtystal Method

目的:建立一种从天然植物中得到其高纯度主要成分的方法,以大黄酸为例进行研究。方法:色谱柱:通过形成共晶从中药大黄得到高纯度的大黄酸。以大黄酸为主药(API),选择精氨酸为共晶形成物(CCF),形成共晶。结果:所得的精制大黄酸纯度可达99.9%。结论:共晶法操作简单,重复性较好,在天然植物成分提取纯化方面有很好的应用前景。

Objective ：To establish an effectitive method for preparative isolation and purification of Chinese medicinal plant components,rhein was taken as the example. Method：Rhein,the major active ingredients of the traditional Chinese medicine Radix et Rhizoma Rhein ,has been separated and purified through the cocrystal method. Rhein was taken as the active pharma- ceutical ingredient（API）,arginine as the cocrystal former （CCF）. Results：The purity of refined rhein can be up to 99.9%. Conclusion ：the cocrystal method had .simple operation and better repeated property. So it is believed that the cocrystal method has a good application prospect in preparative isolation and purification of Chinese medicinal plant components.