雷公藤多苷与环磷酰胺对照治疗肾病综合征的Meta分析

Meta-Analysis on Clinical Therapeutic Effects of Tripterygium Glycosides on Nephrotic Syndrome Compared with Cytoxan

目的:比较雷公藤多苷片(TG)及环磷酰胺(CTX)治疗肾病综合征的疗效(显效率、总有效率),为临床应用雷公藤多苷片治疗肾病综合征提供指导。方法:按系统评价的要求,以雷公藤多苷/环磷酰胺/糖皮质激素/肾病综合征(中英文)为检索词,在1979年—2011年在国内公开发表的中英文文献,统一纳入标准和排除标准,所得文献进行Meta分析。结果:雷公藤多苷片联合泼尼松治疗肾病综合征的显效率(OR=1.00,95%CI为0.57～1.75)和总有效率(OR=0.87,95%CI为0.41～1.85)与CTX联合泼尼松的疗效没有显著性差异。显效率、总有效率、复发率"漏斗图"图形基本对称。结论:雷公藤多苷片联合泼尼松与CTX联合泼尼松治疗肾病综合征的疗效相当。

Objective ： To assess the clinical effects of the tripterygium glycosides （TG） and cytoxan （ CTX ） for nephrotic syndrome（NS）. Methods：With tripterygium glycosides/cytoxan/glucocorticoid/nephrotic syndrome（NS） as the searching words, and with the same inclusion and exclusion criteria, related Chinese and English literatures were retrieved. A Meta analysis was carried out. Results ： Compared with control group, the significant efficiency （ OR = 1.00,95 % CI 0. 57 - 1.75） and total efficiency（ 0 = 0.87,95% CI 0.41 ~ 1.85 ）in treating group had no significant difference. Funnel plots were nearly symmetry. Conclusions：TG and GC have certain effects on treating NS, and the total efficiency is significantly same as CTX and GC. Their definite effects for NS will be further confirmed by multiple - center,large - sample RCT.