甲状腺功能亢进症患者血浆Ghrelin水平的变化及其相关因素分析

Changes of plasma Ghrelin level and analysis of its related factors in hyperthyroidism patients

目的:探讨甲状腺功能亢进症(甲亢)患者血浆饥饿素(Ghrelin)水平变化及其影响因素。方法:选取100例甲亢患者(甲亢组)及40例正常成人(对照组)为研究对象,测定甲亢组治疗前后和正常组的Ghrelin、甲状腺激素水平,并分析Ghrelin水平的影响因素。结果:甲亢组治疗前的Ghrelin水平显著低于对照组,差异有统计学意义(P<0.05),治疗后与对照组比较差异无统计学意义(P>0.05)。相关性分析表明,Ghrelin水平与FT3、FT4呈负相关,与S-TSH呈正相关(P<0.05)。Ghrelin水平与全身肌肉量、体重呈正相关(P<0.05),与脂肪量无相关性(P>0.05)。结论:甲亢患者伴随着血浆Ghrelin水平的降低,可能与甲状腺激素抑制了血浆Ghrelin的分泌有关。

Objective： To investigate changes of plasma Ghrelin level and analysis of its related fac- tors in e hyperthyroidism （Graves） 40 cases of normal adult （the contr patient. Methods： A total of 100 Graves patients （Graves group） and ol group） were chosen as the research object. Ghrelin and thyroid hor- mone levels were determined, risk factors of Ghrelin levels was analyzed. Results：Ghrelin in the Graves group was significantly lower than that in the control group before treatment （P〈0.05）, but two groups had no significant difference after treatment （P〈0.05）. Correlation analysis showed that, Ghrelin level was negatively correlated with FT3, FT4, positively correlated with S--TSH （P〈O. 05）. Ghrelin levels and systemic muscle volume, weight was positively related （P〈O. 05）, but had no relation with {at mass （P〈0.05）. Conclusions. Hyperthyroidism patients always have decreased plasma Ghrelin level, it may be associated with suppression of plasma Ghrelin secretion by thyroid hormone.