血浆活化蛋白C抵抗、抗心磷脂抗体与妊娠期高血压疾病相关性研究

Correlation of plasma activated protein C resistance,anticardiolipin antibody and hypertensive disorder complicating pregnancy

目的:探讨血浆活化蛋白C抵抗(APCR)、抗心磷脂抗体(ACA)与妊娠期高血压疾病相关性。方法:分析比较妊娠期高血压患者血浆内APCR与ACA的阳性率,并对其与妊娠期高血压疾病的发病进行相关性研究。结果 :妊娠期高血压疾病发病与APCR的浓度有明显关系(χ2=7.988,P<0.05),也与ACA-IgG的浓度有显著关系(χ2=14.311,P<0.05),但与ACA-IgM的相关性不明显(χ2=1.118,P>0.05);APCR阳性患者的ACA-IgG阳性率显著高于APCR阴性组(χ2=29.799,P<0.05)。结论:APCR和ACA-IgG是妊娠期高血压疾病的高危因素,ACA-IgG可能通过引起APCR最终导致高血压疾病。

Objective. To evaluate the correlation of plasma activated protein C resistance, anticar- diolipin antibody and hypertensive disorder complicating pregnancy. Methods： The positive rate of ACA, APCR, hypertensive disorder complicating pregnancy of disease and the correlation were analyzed in the plasma. Results. APCR and ACA-IgG were obviously relevant to hypertensive disorder complicating preg nancy（x2= 7. 988, P〈0.05; x2= 14. 311, P〈0.05）; APCR was obviously relevant to ACA-IgG（x2= 29. 799,P〈0.05）. Conclusions： APCR and ACA are risk factors of hypertensive disorder complicating pregnancy, and ACA-IgG contributes to acquired APCR.