醋酸甲羟孕酮在子宫内膜不典型增生治疗作用研究

目的探讨醋酸甲羟孕酮在子宫内膜不典型增生治疗作用研究。方法选取2008年6月～2011年6月收治的子宫内膜不典型增生患者60位,将轻中重三组患者分为A、B、C三组,所有患者均采用醋酸甲羟孕酮治疗,且均于诊刮术后5d开始服药。并根据病理检查结果评价疗效及复发情况。结果 A组患者总有效率为100.0%,B组患者为69.0%,C组为40.0%,三组患者总有效率有显著差异,差异有统计学意义(P<0.05)。C组患者复发率显著高于A、B两组,差异有统计学意义(P<0.05)。结论醋酸甲羟孕酮治疗子宫内膜不典型增生对于要求生育能力的患者具有很好的疗效,复发概率较小,可以作为临床治疗首选方法。

Objective Explore medroxyprogesterone acetate treatment of the role of research in endometrial atypical hyperplasia. Methods Select our hospital from June 2008 to June 2011 were treated endometrial dysplasia in patients with 60, light weight three groups of patients divided into three groups A, B, C, all the patients were treated with medroxyprogesterone acetate pregnancyThe ketones treatment, and are after curettage 5 d medication. And according to the results of the pathological examination to evaluate the efficacy and recurrence. Results A group of the total effective rate was 100.0%. Group B was 69.0%. Group C was 40.0%. The three groups of patients with total efficiency and a significant difference, and the difference was statistically significant （P〈0.05）. Group C patients relapse rate was significantly higher than A, B groups, the difference was statistically significant （P〈0.05）. Conclusion Medroxyprogesterone acetate treatment of atypical endometrial hyperplasia to require fertility patients have a good effect, low probability of recurrence, as the preferred method of clinical treatment.