伴有2型糖尿病牙周炎患者牙周基础治疗后血糖水平和疗效观察

Blood glucose levels and clinical efficacy of periodontitis patients associated with type 2 diabetes after periodontal therapy

目的研究伴有2型糖尿病的牙周炎患者在牙周基础治疗后的血糖水平变化和临床疗效。方法选取泰安市口腔医院伴有2型糖尿病的牙周炎患者51例作为研究组,另选取无糖尿病史牙周炎患者50例作为对照组,两组均行牙周基础治疗,研究组同时行良好糖尿病治疗。对比观察两组在治疗前和治疗后1、8、12周的斑菌指数(PLI)、探针深度(PD)、附着丧失(CAL)、龈沟出血指数(SBI)变化,以及研究组的糖化血红蛋白(HbA1c)和空腹静脉血糖(FPG)变化。结果两组患者的各牙周临床指标(PLI、PD、CAL、SBI)在牙周基础治疗后均得到明显改善(P<0.05),两组间比较差异无统计学意义(P>0.05);研究组在治疗后1周的HbA1c和FPG无显著改善(P>0.05),治疗后8周显著降低(P<0.05或P<0.01);治疗后12周有所反弹但差异无统计学意义(P>0.05)。结论伴有2型糖尿病的牙周炎患者在良好糖尿病治疗基础上应用牙周基础治疗,短期疗效与无糖尿病史患者疗效相当,确切而稳定,并能显著改善血糖,可在临床推广应用及进一步研究。

Objective To study blood glucose levels and clinical efficacy of periodontitis patients associated with type 2 diabetes after periodontal therapy. Methods 51 cases periodontitis patients with type 2 diabetes in Stomatological Hospital of Taian City were selected as research group, 50 patients periodontitis patients without diabetes were selected as control group. Periodontal treatment was adopted in all the patients, good diabetes treatment was adopted in the research group at the same time. It was observed comparative what include plaque bacteria index, attachment loss, sulcus bleeding index, probe depth in two groups, and glycated hemoglobin and fasting venous plasma glucose in the research group. Results The clinical periodontal indexes （PLI, PD, CAL, SBI） were improved obviously after periodon- tal therapy （P〈 0.05）, and compared with the comparison group, the differences was no statistically significant when the clinical periodontal indexes was tested in two groups （P 〉 0.05）. It wasn＇t improvment obviously what include HbA and FPG one week after treatment （P 〉 0.05）, and it was improvement obviously 8 week after treatment （P 〈 0.05 or P 〈 0.01）, and it rebounded 12 week after treatment （P 〉 0.05）. Conclusion Periodontal therapy can be appli- cated widely in clinical and further study, when it apply to patients with periodontitis associated with type 2 diabetes on the basis of good diabetes treatment, because of its short-term curative effect and stable and improvement of blood blood glucose levels significant.