匹多莫德对哮喘患儿发作次数、肺功能及免疫功能的影响研究

Study on the influence of Pidotimod on attack times,pulmonary function and immune function of children with asthma

目的观察匹多莫德对哮喘患儿发作次数、肺功能及免疫功能的影响。方法选择2011年10月～2012年2月河北省保定市儿童医院诊治的76例哮喘患儿作为研究对象,将所有患儿分为对照组(36例)和观察组(40例),对照组采用常规治疗,观察组加用匹多莫德,比较两组哮喘患儿的发作次数、肺功能及免疫功能。结果治疗后,观察组的哮喘发作次数明显少于对照组,差异有统计学意义(P<0.05);观察组患儿的用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、最大呼气流量(PEF)改善情况明显优于对照组,差异有统计学意义(P<0.05);观察组患儿的血清免疫球蛋白IgA、IgG、IgE改善情况明显优于对照组,差异有统计学意义(P<0.05)。结论匹多莫德能够明显减少哮喘患儿的发作次数,并改善患儿的肺功能及免疫功能,是临床首选的治疗药物之一。

Objective To observe the influence of Pidotimod on attack times, pulmonary function and immune function of children with asthma. Methods 76 children with asthma in the Children＇s Hospital of Baoding City of Hebei Province from October 2011 to February 2012 were selected and divided into two groups： 36 cases of control group and 40 cas es of observation group, the control group was treated with conventional therapy, the observation group was added Pi- dotimod therapy, the attack times, pulmonary function and immune function of two groups were compared and ana-lyzed. Results After treatment, the number of asthma attacks of observation group was signifcantly less than control group, the difference was statistically significant between two groups （P 〈 0.05）; the forced vital capacity （FVC）, one sec- ond forced expiratory volume （FEVj）, peak expiratory flow （PEF） of observation group improved more significantly than the control group, the differences were statistically significant between two groups （P 〈 0.05）; the serum immunoglobu- lin IgA, IgG, IgE of observation group improved more significantly than the control group, the differences were statistically significant between two groups （P 〈 0.05）. Conclusion Pidotimod in the treatment of children with asthma can ef- fectively reduce the number of asthma attacks, and improve pulmonary function and immune function, it is one of the preferred clinical therapeutic drug.