阿托伐他汀钙联合尼可地尔对经皮冠状动脉介入治疗患者的心脏保护作用

Heart protection of patients with percutaneous coronary intervention by Atorvastatin Calcium and Nicorandil

目的探讨阿托伐他汀钙联合尼可地尔对经皮冠状动脉介入治疗患者的心脏保护作用。方法应用随机数字表法将2010年6月～2012年6月在大连医科大学附属第一医院心内科收治的96例经皮冠状动脉介入治疗患者分为A组和B组,A组患者给予常规抗心绞痛药物治疗,而B组患者则加用阿托伐他汀钙联合尼可地尔治疗。观察比较两组患者术中心绞痛发作、心电图变化、肌酸激酶同工酶值和左心室射血分数情况。结果 B组患者术中心绞痛和心电图改变明显少于A组,差异有统计学意义(P<0.05),肌酸激酶同工酶值在术后24 h内有升高趋势,术后各时段B组肌酸激酶同工酶值要低于A组,差异有统计学意义(P<0.05),而术后各时段B组左心室射血分数要高于A组,差异有统计学意义(P<0.05)。结论围术期应用阿托伐他汀钙联合尼可地尔能够明显减少经皮冠状动脉介入治疗患者术中心绞痛发作和心电图变化,减轻患者心肌损伤,明显改善患者术后心脏功能。

Objective To investigate the heart protection of patients with percutaneous coronary intervention by Atorvastatin Calcium and Nieorandil. Methods The clinical data of ninety six patients with pereutaneous coronary intervention who were in the department of cardiology in the first affiliated hospital of Dalian medical university from June 2010 to June 2012 were collected, and they were divided into group A and group B by a random number table. The patients in group A were given routine angina pectoris drug therapy, but the patients in group B were given Atorvastatin Calcium and Nieorandil on the basis of the routine angina pectoris drug therapy, then the art center colic attacks, electrocardiogram changes, creatine kinase isozyme value and left ventricular ejection fraction were observed and compared. Results The occurrence rate of art center colic attacks, electrocardiogram changes in group B were signifi- cantly lower than those in group A （P 〈 0.05）; creatine kinase isozyme value within 24 hours rised, it was lower in group B than that in group A after the operation （P 〈 0.05）; left ventricular ejection fraction in group B were signifi-candy higher than those in group A （P 〈 0.05）. Conclusion Atorvastatin Calcium and Nieorandil in the treatment of patients with percutaneous coronary intervention can significantly reduce art center colic attacks and electrocardiogram changes, reduce the patients with myocardial damage and greatly improve the patients heart function.