区域缓释化疗在乳腺癌改良根治术中的应用

Application of regional sustained-release chemotherapy to modified radical mastectomy of breast cancer

目的探讨乳腺癌改良根治术使用缓释型氟尿嘧啶对预防术后局部复发的价值。方法将28例乳腺浸润性导管癌患者随机分为2组,其中治疗组13例,在乳腺癌改良根治术结束后,直视下于手术区域撒布缓释型氟尿嘧啶500 mg;对照组15例,除不使用缓释型氟尿嘧啶外,其他处理同治疗组。结果经中位随访27个月,治疗组没有发现局部复发,对照组有4例出现局部复发,二者之间差异显著(χ2=4.044,P<0.05)。结论缓释型氟尿嘧啶手术区域使用有助于预防乳腺癌术后局部复发,提高乳腺癌综合疗效。

Objective To explore the value of applying sustained - release fluorouracil to the modified radical mastectomy of breast cancer in the prevention of postoperative local relapse. Methods Twenty eight patients with mammary gland infiltrating ductal carcinoma were randomly divided into two groups. Treatment group had 13 cases which received 500 mg fluorouracil spread to the tumor bed region after modified radical mastectomy. Control group had 15 cases which received the same treatment as the former group did except that with sustained - release fluorouracil. Results After 27 months of median follow - up, no local relapse was found in the treatment group. There were 4 cases of local relapse in the control group. There were significant differences in the rate of local relapse between the two groups （χ^2 = 4. 044, P 〈 0.05 ）. Conclusion It is useful to apply sustained - release fluorouracil to the operative region for the prevention of local relapse after modified radical mastectomy and the improvement of the comprehensive curative effects on the breast cancer.