真菌性血流感染菌种分布及耐药性分析

Fungal Species Distribution and Drug Resistance of Bloodstream Infection

目的调查医院血培养标本中真菌的感染状况,为临床诊断和治疗提供依据。方法对本院2011年血培养标本的检测结果进行回顾性分析,并对其中真菌感染进行菌种分布及耐药性分析。结果 2011年1～12月本院送检的血培养标本共5 093份,检出病原菌473株,其中真菌39株,真菌分离率为0.77%,占检出病原菌的7.8%;39株真菌中白色假丝酵母菌数量最多,其次是光滑假丝酵母菌和热带假丝酵母菌;科室分布显示新生儿科数量最多,其次为血液内科和ICU等;39株真菌对5种抗菌药物的敏感率:5-氟胞嘧啶(100.00%)、两性霉素B(97.40%)、伏立康唑(94.90%)、氟康唑(92.30%)、伊曲康唑(89.70%)。结论血流感染真菌以白色假丝酵母菌为主,主要分布在新生儿科,未发现对5-氟胞嘧啶耐药菌株,对抗真菌药物的耐药性均有增加。

Objective To survey the status of fungal infection of blood culture specimen in hospital, and provide the basis for clinical diagnosis and treatment. Methods The retrospective analysis was used to test the results of blood cul- tures in our hospital in 2011, and the distribution and antibiotic resistance for the fungal infections were analyzed. Results Hospital submission of blood culture samples were 5 093 in 2011,473 pathogens were detected, including the detection of 39 fungi. The fungal isolation rate was 0. 77%, accounting for 7. 8% of the pathogens which were detected. The largest number was Candida albicans, followed by Candida parapsilosis and Candida tropicalis. The number of neonatology ranked top in the distribution of the main sections, followed by the department of Hematology and ICU. The sensitivity of 39 fun- gi to the five antimicrohia agents： 5-fluorocytosine （100. 00%）, amphotericin B （97.40%）,voriconazole （94. 90%）, flu- conazole （92. 30%）, itraconazole （89.70%）. Conclusion Candida albicans is the majority of blood infected fungus, which mainly distributed in neonatology. And 5-fluorocytosine resistant strains have not been found, resistance to the antifungal agents have increased.