尼可地尔对慢性充血性心力衰竭患者心脏功能的影响

Effects of Nicorandil on Cardiac Function in Chronic Heart Failure

目的:观察尼可地尔对慢性充血性心力衰竭患者心脏功能的影响。方法:将92例慢性充血性心力衰竭患者随机分为尼可地尔组和常规治疗组。常规治疗组采用常规抗心衰治疗,尼可地尔组在常规治疗的基础上加用尼可地尔。分别检测两组患者治疗前后左室舒张末期内径(LVEDD)、左室射血分数(LVEF)及左室收缩末期内径(LVESD),测定两组治疗前后6min步行距离。结果:与常规治疗组治疗后比较,尼可地尔组LVEDD、LVESD明显减小,LVEF和6min步行距离明显增加(P<0.05)。结论:在常规治疗的基础上加用尼可地尔可进一步改善慢性充血性心力衰竭患者的心功能。

Objective： To explore the effects of nicorandil on cardiac function in patients with chronic heart failure（CHF）. Methods： 92 patients with CHF were randomly divided into nicorandil treatment group and conventional treatment group. The conventional treatment group was given conventional treatment and nicorandil treatment group was given nicorandil on the use of conventional treatment. Two groups of patients were detected left ventricular end diastolic diameter（LVEDD）, left ventricular ejection fraction（LVEF）, left ventricular end diastolic diameter（LVESD）and 6 minute walk test（6MWT） before and after treatment.Results： Compared with the conventional treatment group, LVEDD, LVESD was significantly reduced, and LVEF, 6MWT increased signifieantly in nicorandil treatment group.Conclusion： Nicorandil added on conventional treatment can effectively improve the cardiac function in patients with CHF.