血清胆红素与急性脑梗死病情关系的临床研究

Clinical study on the relationship of acute cerebral infarction severity with serum bilirubin

目的探讨血胆红素与急性脑梗死严重程度的关系。方法 120例急性脑梗死患者分为高DBIL组(DBIL>6.8mmol/L)和低DBIL(DBIL≤6.8mmol/L)组,比较两组传统危险因素和美国国立卫生研究院卒中评分(NIHSS)。回归分析急性脑梗死患者严重程度(NIHSS评分>12分)和血胆红素的相关性。结果高DBIL组NIHSS评分>12分患者比例显著高于低DBIL组,差异有统计学意义;回归分析提示DBIL、高血压史、糖尿病史是急性脑梗死患者严重程度的危险因素。结论急性脑梗死病情与血直接胆红素水平正相关,血直接胆红素水平可以判断急性脑梗死病情。

Objective To explore the relationship of acute cerebral infarction severity with serum bilirubin. Methods One hundred and twenty patients with acute cerebral infarction were divided into high DBIL group （DBIL 〉 6.8 mrnol/L） and low DBIL group （DBIL ≤ 6.8 mmol/L）,relevant data of serum bilirubin and NIHSS scores were gathered. The rela- tionship between bilirubin and NIHSS scores was explored through logistic regression analysis. Results Both serum di- rect bilirubin and total bilirubin were markedly correlated with NIHSS by logistic regression analysis. Conclusion Serum bilirubins were closely correlated with severity of acute cerebral infarction, which may be useful markers for the severity of illness.