脑科医院感染铜绿假单胞菌的耐药分析

Drug resistance analysis of pseudomonas aeruginosa in brain hospital

目的了解本院铜绿假单胞菌(PAE)对常用抗菌药物的耐药现状及标本分布。方法采用法国生物梅里埃生物API鉴定系统进行鉴定,并采用K-B纸片扩散法进行体外耐药检测及耐药率统计。结果临床分离的823株PAE以痰标本的检出率最高(79.7%),主要分布在神经外科(330株,占40.0%),重症监护病房(ICU)(142株,占17.3%),干部病房(105株,占12.8%),神经内科(77株,占9.4%)。铜绿假单胞菌对14种抗菌药物的耐药率呈逐年上升趋势。2012年阿米卡星和头孢哌酮/舒巴坦对铜绿假单胞菌具有较好的抗菌活性,耐药率分别为23.6%和24.2%。结论 PAE是医院感染的主要病原菌之一,加强其耐药性检测,规范抗菌药物的应用,对保持敏感抗菌药物的抗菌活性具有重要意义。

Objective To investigate the distribution and situation of drug resistance of pseudomonas aeruginosa isolat- ed in our hospital. Methods The microbilogical system API was used to indentify pseudomonas aeruginosa while the drug resistance in vitro was determined by K-B methods. Results The 823 strains of pseudomonas aeruginosa were mainly distributed in neurosurgery departments （330 strains, accounted for 40.0%）, ICU （142 strains, accounted for 17.3%）,senior officials inpatient ward （105 strains, accounted for 12.8%） and nervous departments （77 strains, ac- counted for 9.4%）, 79.7% of them came from sputum specimens. The drug resistance of pseudomonas aeruginosa a- gainst 14 kinds of all appeared an increasing trend year and year. The antibacterial activity of Amikacin and Cefoper- azone/Sulbactam to pseudomonas aeruginosa were superior in 2012, with average resistance rate~ as 23.6% and 24.2%. Conclusion Pseudomonas aeruginosa is one of the main pathogenic bacteria in nosocomial infection, so reinforce the monitoring on the drug resistance of pseudomorias aeruginosa and to standardize the application of antibacterials are helpful to maintaining antibacterial activity of sensitive antibacterials.