摘要
目的观察SOX4蛋白在大肠癌组织中的表达变化,并探讨其意义。方法采用免疫组化SP法对大肠正常黏膜及原发大肠癌组织中的SOX4蛋白进行检测。结果 SOX4蛋白在大肠癌组织中的表达水平显著高于大肠正常黏膜组织(P<0.01);有淋巴结转移的大肠癌组织中SOX4蛋白表达水平明显高于无淋巴结转移者(P<0.01);SOX4蛋白表达水平与癌组织浸润肠壁深度有关(P<0.01),而与癌细胞分化程度无关(P>0.05)。结论SOX4蛋白在大肠癌组织中高表达,与大肠癌的浸润转移有关,可作为大肠癌发生发展的预测指标之一。
Objective To observe the changes of SOX4 protein expression in colorectal carcinoma(CRC) and investi- gate the significance. Methods The expression of SOX4 protein in normal colorectal mucosae and primary CRCs was de- tected using immunohistochemistry. Results The expression levels of SOX4 protein in CRC tissues were significantly high- er than those in normal colorectal mucosa tissues (P 〈 0.01 ). The expression of SOX4 protein in CRCs with lymph node metastasis was significantly higher than those without lymph node metastasis (P 〈 0.01 ). The SOX4 protein expression, showing no correlation with the differentiation of CRC ( P 〉 0.05 ), was positively correlated with the infiltrating depth of carcinomas (P 〈 0.01 ). Conclusion SOX4 protein, highly expressed in CRCs, is related to the infiltrating and metasta- sis of CRC and might be a valuable marker for the carcinogenesis and progression of CRC.
出处
《山东医药》
CAS
2013年第15期10-12,共3页
Shandong Medical Journal
基金
高等学校博士学科点专项科研基金资助项目(20094422120010)
广东省医学科研基金资助项目(A2010346)
南方医科大学基础医学院院长基金资助项目(JC0904)
关键词
大肠肿瘤
大肠癌
Y染色体性别决定区域
SOX基因
SOX4蛋白
colorectal neoplasms
colorectal carcinoma
sex-determining region of Y chromosome
SRY-related HMG-box gene
SOX4 protein