大肠癌组织中SOX4蛋白的表达变化及意义

Expression and significance of SOX4 protein in colorectal carcinoma

目的观察SOX4蛋白在大肠癌组织中的表达变化,并探讨其意义。方法采用免疫组化SP法对大肠正常黏膜及原发大肠癌组织中的SOX4蛋白进行检测。结果 SOX4蛋白在大肠癌组织中的表达水平显著高于大肠正常黏膜组织(P<0.01);有淋巴结转移的大肠癌组织中SOX4蛋白表达水平明显高于无淋巴结转移者(P<0.01);SOX4蛋白表达水平与癌组织浸润肠壁深度有关(P<0.01),而与癌细胞分化程度无关(P>0.05)。结论SOX4蛋白在大肠癌组织中高表达,与大肠癌的浸润转移有关,可作为大肠癌发生发展的预测指标之一。

Objective To observe the changes of SOX4 protein expression in colorectal carcinoma（CRC） and investi- gate the significance. Methods The expression of SOX4 protein in normal colorectal mucosae and primary CRCs was de- tected using immunohistochemistry. Results The expression levels of SOX4 protein in CRC tissues were significantly high- er than those in normal colorectal mucosa tissues （P 〈 0.01 ）. The expression of SOX4 protein in CRCs with lymph node metastasis was significantly higher than those without lymph node metastasis （P 〈 0.01 ）. The SOX4 protein expression, showing no correlation with the differentiation of CRC （ P 〉 0.05 ）, was positively correlated with the infiltrating depth of carcinomas （P 〈 0.01 ）. Conclusion SOX4 protein, highly expressed in CRCs, is related to the infiltrating and metasta- sis of CRC and might be a valuable marker for the carcinogenesis and progression of CRC.