流行性腮腺炎合并肝损伤的临床分析

Clinical analysis on mumps complicated with liver injury

目的通过分析流行性腮腺炎并发肝损伤的临床特征,为相关疾病的预防、诊断和治疗提供临床及实验室依据。方法回顾性分析吉林省肝胆病医院2010年8月～2012年8月于本院住院治疗的7例流行性腮腺炎合并肝损伤病例的临床资料。结果 68例流行性腮腺炎患者中有7例(10.3%)合并肝损伤,其中男性6例(85.71%),女性1例(14.29%),年龄18～30岁。临床表现为腮腺肿大、发烧伴有明显恶心、乏力,肝损伤主要以ALT升高为主,胆汁淤积情况少见,超声显示有肝脏肿大患者4例(57.14%)。经过抗病毒、抗氧化保肝以及对症治疗,其中5例患者痊愈出院,2例好转出院。结论 18岁以上的流行性腮腺炎患者更易并发肝损伤,建议将肝功能和腹部彩色超声作为常规检查项目,尤其对青年患者应给予足够的重视。

Objective To analyse cinical symptoms of patients with mumps supervene with liver damage, and provide clinical and experimental basis on prevention, diagnosis and treatment for related diseases. Methods Total of 7 cases with mumps supervened with liver damage in Hepatology Hospital of Jilin Province during August 2010 to August 2011 were collected and the clinical data were collected, retrospectively. Results There were 7 patients who were with mumps complicated with liver injury among the 68 cases （ 10.3% ）, including 6 （85.71%） males and 1 （ 14.29% ） female, whose ages varied from 18 to 30. The clinical manifestations were parotid gland enlargement, fever accompanied by significant nausea and fatigue symptoms. Liver injury mainly manifested as an increase of ALT, rarely as cholestasis, and 4 cases with hepatomegaly under ultrasonography （57. 14% ）. Antiviral therapy, hepatoproteetive medicine application with symptomatic treatment to the patients, combined which 5 cases were cured and 2 cases improved and discharged. Conclusions Patients with mumps of 18 years or older are more prone to be complicated with liver injury. Hepatic function detection and abdominal ultrasonography are recommended as routine examination items. More attention should be paid to young patients.