Gluma脱敏剂治疗牙本质过敏症疗效的系统评价

Therapeutic Efficacy of Gluma Desensitizer for Dentine Hypersensitivity:a Systematic Review

目的:系统评价Gluma脱敏剂治疗牙本质过敏症(DH)的疗效,为DH治疗方案提供选择依据。方法:计算机检索中国生物医学文献数据库、中国期刊全文数据库、Pubmed、EMbase和Cochrane central register of controlled trials数据库,对数据采用Rev Man 5.1.2和Stata 11.0统计软件进行Meta分析。结果:共纳入19项研究,合计3828颗患牙。Meta分析结果显示,Gluma脱敏剂治疗DH的即刻[OR=5.04,95%CI(3.48,7.31),P<0.01]、1个月[OR=3.28,95%CI(2.23,4.83),P<0.01]、3个月[OR=5.67,95%CI(3.12,10.29),P<0.01]和6个月[OR=4.51,95%CI(2.36,7.74),P<0.01]疗效均优于75%氟化钠;而Gluma脱敏剂与极固宁脱敏剂疗效比较差异无统计学意义。结论:Gluma脱敏剂治疗DH疗效优于75%氟化钠,而与极固宁脱敏剂无差别。但鉴于分析极固宁脱敏剂的研究较少和纳入的文献质量相对不高,此次研究的结论要谨慎对待。

OBJECTIVE： To evaluate therapeutic efficacy of Gluma desensitizer for dentine hypersensitivity （DH） systematical- ly, and to provide reference for the selection of treatment regimen for DH. METHODS： Systematic searches of CBM, CNKI, Pubmed, EMbase and Cochrane Central Register of Controlled Trials databases were performed. Meta-analysis was performed by Review Manager 5.1.2 and Stata 11.0 software. RESULTS： A total of 19 studies were included, involving 3 828 patients. Results of Meta-analysis showed that the immediate effective rate [OR：5.04, 95%CI（3.48,7.31） ,P〈0.01], 1-month effective rate [OR： 3.28, 95%CI（2.23,4.83）,P〈0.01], 3-month effective rate [OR：5.67, 95%CI（3.12, 10.29）,P〈0.01] and 6-month effective rate [OR：4.51, 95% CI （2.36, 7.74）, P〈0.01] of Gluma were all higher than those of 75% sodium fluoride. For Gluma vs. Gree- nOrTM, no significant difference was found. CONCLUSION： Gluma desensitizer can effectively relieve DH pain than 75% sodium fluoride but for GreenOrTM. Considering small number of studies for comparison between Gluma and GreenOrTM and low quality of studies included, this conclusion should be interpreted with caution.