安宫牛黄丸治疗颅脑损伤合并中枢性高热症患者的临床观察

Clinical Observation of Angong Niuhuang Pills for Cranial Trauma Complicating with Central High Fever

目的:观察安宫牛黄丸治疗颅脑损伤合并中枢性高热症患者的临床疗效。方法:将60例颅脑损伤合并中枢性高热症患者随机均分为试验组和对照组。在常规治疗的基础上,对照组患者给予糖皮质激素加物理降温治疗,试验组患者在对照组基础上加用安宫牛黄丸。将1丸溶于50ml注射用水中,对于呕吐、意识模糊、吞咽功能异常及伴有呼吸障碍的患者经灌肠法给药,对于未见呕吐、意识模糊及呼吸正常的患者经胃管给药,对于意识清晰、吞咽功能正常的患者经口服给药,bid。两组患者疗程均为3d。观察两组患者的临床疗效、炎症因子水平及肝、肾功能等指标。结果:治疗后,对照组患者的总有效率为73.3%(22/30),试验组为93.3%(28/30),试验组显著高于对照组(P<0.05);试验组肿瘤坏死因子α、总胆红素、C反应蛋白水平均有所下降,与对照组比较差异有统计学意义(P<0.05)。治疗过程中,两组患者肝、肾功能指标均未见异常改变。结论:安宫牛黄丸对脑部损伤合并中枢性高热症患者疗效确切,短期服用安全。

OBJECTIVE： To explore clinical efficacy of Angong niuhuang pills for cranial trauma complicating with central high fever. METHODS： 60 patients with cranial trauma complicating with central high fever were randomly divided into 2 groups. Control group was additionally treated with glucocorticoid and physical cooling treatment on the basis of conventional treatment. Ex- perimental group was additionally given Angong niuhuang pills on the basis of the treatment of control group. 1 pill of Angong ni- uhuang pills was dissolved in water for injection 50 ml, and then given patients with vomiting, mental confusion and swallowing function disorder complicating with respiratory disorder with enema administration; patients without vomiting, mental confusion and respirator disorder were given medicine via gastric tube; patients with clear awareness and normal swallowing function were given medicine orally, bid, for 3 days. Clinical efficacies, inflammatory factors, liver and kidney function and other indicators were observed in 2 groups. RESULTS： After treatment, the total effective rate of control group was 73.3% （22/30） and that of ex- perimental group was 93.3% （28/30）, that of experimental group higher than that of control group （P〈0.05） ; tumor necrosis fac- tor-a, total bilirubin and C-reactive protein decreased in trial group, and there was statistical significance between 2 groups （P〈 0.05）. There was no change in the liver and kidney function. CONCLUSION： Angong niuhuang pills are effective for cranial trauma complicating with central high fever and safe in short-term.